纳洛酮对大鼠伏核注入加压素增强电针镇痛作用的影响  

The Effects of Naloxone on Electroacupuncture Analgesia Induced by Injection of Arginine-Vasopressin into Nucleus Accumbens in Rats

作　　者：黄碧兰[1] 吕承云[1] 涂宗苹 骆红艳[1] 

机构地区：[1]湖北省咸宁医学院生理学教研室,郧阳医学院生理教研室,同济医科大学基础医学院生理学教研室

出　　处：《同济医科大学学报》1996年第6期432-435,共4页Acta Universitatis Medicinae Tongji

摘　　要：以辐射热甩尾法的甩尾潜伏期作为痛阈，观察纳洛酮（ＮＡＬ）对伏核注入精氨酸加压素（ＡＶＰ）能提高痛阈及增强电针镇痛作用的影响。结果：伏核内微量注入ＡＶＰ（０．０１５Ｕ），大鼠痛阈提高，针刺镇痛效应明显增强。伏核预先注入ＮＡＬ（０．８μｇ），明显削弱ＡＶＰ的镇痛和增强电针镇痛作用。１、２、３Ｖ电针的平均针效与对照组比较减弱了３７％（Ｐ＜０．０１），电针后效由４０ｍｉｎ缩短为２０ｍｉｎ。结果表明，ＡＶＰ参与痛觉调节过程，并在电针镇痛过程中发挥一定的作用。这种作用部分是由内源性阿片肽系统中介的。The rat's tail-flick latency of radiant heat tail-flick test was taken as the index for pain threshold(PT).The effects of naloxone(NAL) on PT and electroacupuncture(EA) analgesia induced by nucleus accumbens(NA) injection of arginine-vasopressin(AVP) were observed.Microinjection of AVP(0.015 U) into NA raised the PT and obviously enhanced the EA analgesic effect.The NA preinjection of NAL(0.8μg) obviously weakened the analgesia of AVP and strengthened the EA analgesia of AVP.The mean analgesic effect of 3 steps(1,2,3 V) during EA was weakened by 37%(P<0.01),as compared with the control group,and the EA after-effect was shortened from 40 to 20 min.Our results showed that AVP takes part in the regulating process of sense of pain and plays a role in the course of EA analgesia,which is partly mediated by the endogenous opioid peptide.

关 键 词：精氨酸 加压素 纳洛酮 伏核 痛阈 电针 镇痛 

分 类 号：R971.1[医药卫生—药品] R245.97[医药卫生—药学]