国产左旋18－甲基炔诺酮宫内节育器缓释系统体外释放率的测定  

Determination on In Vivo Release of Delivery System in LNG-IUD

作　　者：吴昌杰[1] 李儒镠 

机构地区：[1]同济医科大学计划生育研究所

出　　处：《同济医科大学学报》1996年第6期453-454,466,共3页Acta Universitatis Medicinae Tongji

基　　金：国家计划生育委员会资助

摘　　要：对随机取样的５支样品进行了７０～８８ｄ的测试，结果表明该系统的释放量在５．３７～６．５５μｇ／ｄ，该系统累积释放量与时间成正比，相关系数在０．９９８以上，符合零级动力学规律。The daily daily release amount of 5 randomly chosen samples on 77～88 th days was examined.The result showed that delivery amount of the system was 5.37～6.65 μg/d.The accumulative delivery amount is proportional to time.The relation coefficient was 0.998.The in vivo delivery pattern conformed to profile of zero order drug release dynamics.

关 键 词：18-甲基炔诺酮 缓释系统 释放速率 宫内节育器 

分 类 号：R979.21[医药卫生—药品] R169.41[医药卫生—药学]