普鲁卡因胺对小鼠肺栓塞和血小板MDA生成的影响  

Effect of procainamide on pulmonary thromboembolism and platelet malondialdehyde in mice

作　　者：庞建新[1] 孙莉莎[1] 王晓燕[1] 杨素琴[1] 单春文[1] 

机构地区：[1]第一军医大学药理教研室

出　　处：《中国药理学报》1996年第6期500-502,共3页Acta Pharmacologica Sinica

摘　　要：普鲁卡因胺对小鼠肺栓塞和血小板ＭＤＡ生成的影响庞建新，孙莉莎，王晓燕１，杨素琴，单春文（第一军医大学药理教研室，广州５１０５１５，中国）关键词普鲁卡因胺；血检形成；丙二醛；血小板聚集目的：探讨普鲁卡因胺（ＰＡ）对肺栓塞，血小板丙二醛（ＭＤＡ）及血小板...IM: To study the effect of procainamide (PA) on pulmonary thromboembolism, platelet malondi￣aldehyde (MDA) level and platelet aggregation induced by collagen and adrenaline. METHODS: Pulmonary thromboembolism, 2 thiobarbituric acid fluorescence micro determination, conventional microscopic counting, and platelet aggregation test were used. RESULTS: PA (10-20 mg ·kg -1 ) and mannitol (200 mg·kg -1 ) reduced thrombosis by 30 % -75 % and 75 % , respec￣tively. Thrombocytopenia followed thrombosis increased after the pretreatment of PA and mannitol. MDA decreased by both of them in vivo. In vitro , PA inhibited platelet aggregation and MDA production induced concentration dependently by collagen and adrenaline. CONCLUSION: Inhibition of PA on pulmonary thromboembolism is involved in the decrease of platelet aggregation and MDA production.

关 键 词：普鲁卡因胺 血检形成 丙二醛 血小板聚集 

分 类 号：R973[医药卫生—药品] R965.1[医药卫生—药学]