血凝酶与抑肽酶在人工关节置换术中的应用  

Application of Hemocoagulase and Aprotinin in Prosthetic Replacement of Joint

作　　者：刘唐生[1] 王心田[2] 李荣胜[2] 

机构地区：[1]广州市白云区中医医院,广州市510450 [2]广州中医药大学第一附属医院,广州市510405

出　　处：《中国药房》2006年第24期1885-1886,共2页China Pharmacy

摘　　要：目的:评价血凝酶与抑肽酶减少手术出血量的效果及安全性。方法:75例全髋关节置换术患者随机分为Ⅰ、Ⅱ、Ⅲ组,每组25例。术前15min,3组分别静脉注射血凝酶2kU、抑肽酶278IU、注射用水10ml。结果:Ⅰ、Ⅱ组术后24h出血量及术后输血量分别为(286.9±65.6)、(301.9±81.1)ml及(101.8±29.6)、(98.3±36.1)ml,比Ⅲ组的(369.2±59.3)、(220.2±48.5)ml显著减少(P<0.01)。3组术毕血红蛋白、血小板、纤维蛋白原比术前明显降低(P<0.01),但均在正常范围。Ⅱ组有1例发生严重过敏反应。结论:术中应用血凝酶或抑肽酶均有明显的止血效果,但血凝酶更安全。OBJECTIVE： To evaluate the efficacy of hemocoagulase and aprotinin in reducing bleeding volume and to evaluate their medication safety.METHODS： 75 patients undergoing total hip replacement were randomly assigned to receive hemoeoagulase 2kU（Group Ⅰ ）,aprotinin 2781U（Group Ⅱ ） or water for injection 10ml（Group Ⅲ ） intravenously before operation, with 25 cases in each group.RESULTS：Total 24h bleeding volume vs.blood infusion volume after operation in Group and Group Ⅱ were （286.9 ± 65.6） ml vs. （301.9 ± 81.1） ml and （ 101.8 ± 29.6） ml vs. （98.3 ± 36.1） m l, respectively, which were significantly lower as against Group Ⅲ（369.2± 59.3）ml vs.（220.2± 48.5）ml （P〈0.01）.Postoperative levels of Hb,BPC and FIB were significantly lowered as against before operation（P〈0.01）, but still within normal range.Severe allergic response occurred in one ease of Group Ⅱ .CONCLUSION： Periopcrative use of either hemocoagulase or aprotinin exhibits good heinestatic efficacy,but hemocoagulase is better in safety.

关 键 词：血凝酶 抑肽酶 关节成形术 

分 类 号：R973.1[医药卫生—药品] R982[医药卫生—药学]