贯叶连翘提取物对血管性痴呆大鼠学习行为和组织病理学的保护作用  

Protcective effect of extracts of Hypericum perforatum on learning ability and pathological changes in rats with vasculardementia model

作　　者：孙蓉[1] 刘晓伟[2] 尹建伟 吕丽莉[1] 孙闵[4] 

机构地区：[1]山东省中医药研究院,济南250014 [2]济南市中医院,济南250012 [3]济南杏林生物技术有限公司,济南250101 [4]济宁医学院临床学院,济宁272013

出　　处：《中药药理与临床》2006年第6期36-38,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:研究贯叶连翘提取物防治血管性痴呆的作用。方法:永久性结扎大鼠双侧颈总动脉,采用水迷宫和病理组织学方法观察药物作用。结果:贯叶连翘提取物能降低永久性结扎双侧颈总动脉后24小时内大鼠的死亡率,有降低大鼠水迷宫游出时间和错误次数的趋势,给药30d给药组与对照组相比水迷宫的错误次数显著降低;能防止海马锥体细胞死亡;提高大鼠双侧颈动脉永久性结扎后,海马SS阳性神经元数目。结论:贯叶连翘提取物在治疗血管性痴呆上有一定的开发前景。Objective： To investigate the effect of extracts of Hypericum perforatum on vasculardementia model rats. Methods ： Use rats with permanent bilateral occlusion of common carotidarter iesasa vasculardementia model. Results ： Extracts of Hypericum perforatum decreased the mortality of model rats with in 24 hours after receiving permanent 2 VO operation;could significantly improve the abilith of learning and memory function tested by the water maze,as well as reduced the death of hippocampalpyramidal cells, in 30 days after receiving permanent 2 VO operation. Extracts of Hypericum perforatum could reverse pathophysiological change of the hippocampal SS neurons in model rats. Conclusion： Extracts of Hypericum perforatum might have been prompted definite empoldering foreground in therapeutic effect on vascu）ardementia diseases.

关 键 词：贯叶连翘提取物 血管性痴呆 学习记忆 海马 生长抑素 

分 类 号：R285[医药卫生—中药学]