重症肺炎患儿血清可溶性细胞间黏附分子-1水平的变化及临床意义  

Serum soluble intercellular adhesion molecule-1 in children with severe pneumonia

作　　者：刘纯义[1] 李凯红[1] 黄卫东[1] 陆必森[1] 王世俊[1] 金萍[1] 刘喜[1] 

机构地区：[1]广东省深圳市宝安区妇幼保健院儿科,广东深圳518133

出　　处：《中国小儿急救医学》2006年第6期514-516,共3页Chinese Pediatric Emergency Medicine

基　　金：广东省深圳市科技局2004年度科研资助项目(200405241)

摘　　要：目的探讨重症肺炎患儿血清可溶性细胞间黏附分子-1(sICAM-1)水平的变化,以及不同病原体所致重症肺炎血清sICAM-1的水平及其临床意义。方法采用双抗体夹心酶联免疫吸附法测定40例重症肺炎患儿和43例普通肺炎患儿急性期、恢复期、以及48例健康对照组小儿血清sICAM-1水平。结果重症肺炎急性期血清sICAM-1水平明显高于重症肺炎恢复期,差异有非常显著性(P<0.01);与普通肺炎急性期与健康对照组比较,差异有非常显著性(P<0.01);重症肺炎恢复期血清sICAM-1水平与普通肺炎恢复期及健康对照组比较,则差异均无显著性(P>0.05);重症细菌性肺炎、病毒性肺炎、支原体肺炎、病毒与细菌混合感染性肺炎急性期血清sICAM-1水平比较,差异均无显著性(P>0.05)。结论重症肺炎患儿急性期血清sICAM-1水平较普通肺炎急性期明显增高,但不同病原体所致重症肺炎血清sICAM-1水平变化无统计学意义;sICAM-1参与了重症肺炎的炎症过程,其水平的高低可以作为肺炎病情轻重的判断指标之一。Objective To investigate the changes and clinical significance of serum soluble intercellular adhesion molecule-1 （sICAM-1） in children with severe pneumonia and to ascertain whether the serum sICAM-1 levels are different in the severe pneumonia caused by different pathogens. Methods By double antibody sandwich ELISA technique, serum sICAM-1 levels at acute and recovery stage were determined in 40 children with severe pneumonia and 43 children with mild pneumonia as well as 48 healthy children. Results Serum sICAM-1 level at acute stage of the children with severe pneumonia was remarkably higher than that in recovery stage （ P 〈 0.01）. Meanwhile, Serum sICAM- 1 at acute stage was significantly higher in severe pneumonia group than those in same stage of mild pneumonia group and control group （P〈 0.01）. However, there was no significant difference among the severe pneumonia, the mild pneumonia at recovery stage and the control group （P 〉 0.05 ）. No significant difference in serum sICAM-1 level was present among severe bacterial pneumonia, viral pneumonia, mycoplasmal pneumonia, the viral and bacterial coinfection at their acute stage （ P 〉 0.05）. Conclusion Serum sICAM-1 level of severe pneumonia was remarkably higher than that io the mild pneumonia at acute stage, but there were no significant difference for serum sICAM- 1 among the severe pneumonia caused by the different pathogens. Serum sICAM-1 may be an active inflammatory molecule in the pathogenesis of pneumonia and its level can be regarded as one of the markers in evaluating the severity of pneumonia in children.

关 键 词：重症肺炎 可溶性细胞间黏附分子-1 儿童 

分 类 号：R725.6[医药卫生—儿科]