HPLC法测定风湿定胶囊中丹皮酚含量  被引量:2

Determination of Paeonol in Fengshiding Capsules by HPLC

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作  者:迟归兵[1] 雷岚[1] 袁继民[1] 宋茹[1] 

机构地区:[1]中国人民解放军济南军区药品仪器检验所,山东济南250022

出  处:《解放军药学学报》2006年第6期462-464,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘  要:目的采用HPLC法对风湿定胶囊中丹皮酚含量进行测定。方法Agilent ZORBAXXDB-C18色谱柱(4.6mm×250mm,5μm),流动相为甲醇-水(80:20),检测波长274nm,流速为1ml/min,柱温35℃。结果丹皮酚在0.0313-0.6260μg范围内呈良好的线性关系,r=0.9999,平均回收率为97.5%,供试品溶液在8h内稳定,RSD为1.05%。结论本方法简单、快速、准确,能够获得满意的测定结果。Aim To construct an HPLC method for the determination of paeonol in Fengshiding capsules. Method The HPLC system consisted of C18 column (4.6mm×250mm,5μm), methanol-water(80: 20)as mobile phase, a flow rate(1ml/min) and column temperature at 35℃. Results Paeonol showed a good linear relationship with in a range of 0.031 3 -0.626 0℃g( r =0.999 9) ; the mean recovery was 97.5% ,and the RSD within 8 hours was 1.05%. Conclusion The method is simple and accurate and can be used for quality control in Fengshiding capsules.

关 键 词:HPLC 风湿定胶囊 丹皮酚 

分 类 号:R917[医药卫生—药物分析学]

 

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