高分子材料对尼莫地平/羟丙基-β-环糊精超分子体系溶解与溶出的影响  

Influence of Polymers on the Solubility and Dissolution of Nimodipine/HP-β-CD Supermolecule Systems

作　　者：刘飞[1] 杨星昊[1] 訾鹏[1] 刘海[1] 涂昌兵 

机构地区：[1]南京师范大学新药研究中心,江苏南京210097 [2]山东绿叶制药有限公司,山东烟台264003

出　　处：《南京师大学报（自然科学版）》2006年第4期91-95,共5页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：国家自然科学基金(30371690);江苏省高校自然科学基金资助项目(05KJB350069).

摘　　要：应用相溶解度法比较了高分子(PVP、PEG、HPMC)对HP-β-CD体系稳定性和药物溶解性的影响.采用冷冻干燥和物理混合法,制备了药物/羟丙基-β-环糊精二元体系及三元高分子固体体系,测定了各体系的溶出曲线,采用差示热分析考察了各体系的热性质.研究了常见高分子药用辅料对尼莫地平/羟丙基-β-环糊精包合和溶解性的影响.结果表明,三元体系表观稳定常数KS提高后尼莫地平溶解度较两元体系上升,但溶出速率均有所降低.可见,高分子的加入可以改善HP-β-CD增溶尼莫地平的效果,高分子对尼莫地平/羟丙基-β-环糊精体系的溶出速率的影响较为复杂,与高分子种类及体系中的含量有关.Abstract：The aim is to investigate the influence of polymers on Nimodipine / HP - β - CD binary system Methods：Compare the effect of different polymers（ PVP/PEG/HPMC ） on the stability and solubility with phase - solubility method. Prepare nimodipine/HP - β - CD binary system and nimodipine / HP - β - CD / polymers ternary systems with lyophilization and physical mixed methods. These systems are characterized by thermal analysis （DSC） and dissolution studies. Results：The Ks was increased when the ternary system was formulated . Compare the binary system, the solubility is increased and the dissolution rate is decreased . Conclusion： The addition of polymers can improve the solubilization effect of cyclodextrin. The breed and concentration of polymers can affect the dissolution with a complicated mechanism.

关 键 词：尼奠地平 羟丙基-Β-环糊精 高分子 DSC 溶出度 

分 类 号：R944[医药卫生—药剂学]