培氟沙星在碳糊电极上的阳极吸附伏安法研究  

Anodic adsorptive voltammetric determination of pefloxacin at a carbon paste electrode

作　　者：易兰花[1] 费俊杰[1] 黎拒难[1] 

机构地区：[1]湘潭大学化学学院,湖南湘潭411105

出　　处：《化学试剂》2006年第12期744-746,共3页Chemical Reagents

基　　金：中国科学院长春应用化学研究所电分析化学国家重点实验室基金项目(2005-10);湖南省教育厅青年科研基金项目(05B004)

摘　　要：在O．40mol／L的NaAc-HAc（pH4．9）缓冲液中，使用JP-303极谱分析仪，培氟沙旱在碳糊电极（CPE）上有一灵敏的吸附伏安氧化峰，峰电位为1．03V（vs．SCE）。该氰化峰的二阶导数峰电流与培氟沙星的浓度在8．0×10^-9～8．0×10^-7mol／L（富集90s）范围内成良好的线性关系，相关系数r为0.998，检出限为4．0×10^-9mol／L（S／N=3，富集110s）。探讨了培氟沙星在碳糊电极上的伏安件质和电极反应机理，并且成功应用于胶囊中培氟沙星含量的测定。A highly selective and rapid new anodic adsorptive vohammetric method has been developed for the determination of trace amount of pefloxacin by using a carbon paste electrode （CPE）. The pefloxacin was adsorbed on the surface of the CPE yielding an oxidation peak at 1.03 V （vs. SCE） by using JP-303 polamgraphic analyser in a NaAc-HAc buffer solution 0.40 mol/L （pH 4.9）. The linear relationship between the peak current and pefloxaein concentration lay in the range of 8.0 × 10^-9 - 8.0 × 10^-7 mol/L （90 s accummulation） .The correlation coefficient was 0. 998. Its detection limit was 4.0 × 10^-9 mol/L （S/N = 3） for a 110 s accummulation. The mechanism of the electrode reaction of pefloxacin has been investigated. The proposed method can be applied to direct determination of pefloxacin in the capsules with satisfactory results.

关 键 词：培氟沙星 阳极吸附伏安法 碳糊电极 

分 类 号：O657.1[理学—分析化学]