海洛因依赖者的海马区磁共振氢质子波谱改变  

^1H MR Spectroscopy of Hippocampus in the Heroin- dependent Patients

作　　者：王建国[1] 张建军[2] 董汉彬[1] 胡臣文[1] 马钦华[1] 申大光[1] 

机构地区：[1]深圳市罗湖区人民医院影像中心,广东深圳518001 [2]深圳市公安局强制戒毒所

出　　处：《实用放射学杂志》2006年第12期1433-1435,共3页Journal of Practical Radiology

基　　金：2003年深圳市卫生科技计划项目(编号:200304220)

摘　　要：目的探讨海洛因依赖者的海马区氢质子磁共振波谱(1H MRS)改变。方法对30例自愿戒毒的海洛因依赖者及20例正常对照组进行脑部常规MR I及海马区1H MRS检查,分析海洛因依赖者海马区1H MR I波谱的改变。结果常规MR I扫描,所有检查者海马区均未见异常信号1。H MRS发现海洛因依赖者双侧海马区NAA/Cr低于正常对照组,有显著性差异(P<0.05);Cho/Cr与正常对照组比较无显著性差异。结论1H MRS可以早期显示海洛因的毒性效应造成的海马区神经元功能受损,而此时可不出现形态学改变。Objective To study theZH MR spectroscopy（ ^1H MRS） changes of hippoeampus in the heroin - dependent patients. Methods Conventional MR scanning and ^1H MRS were performed in 30 heroin - dependent patients and 20 normal controls. The changes of conventional MRI and ^1H MRS of the hippoeampus were analyzed. Results No abnormal signal was found at the hippoeampus on conventional MR scanning. ZH MRS of hippoeampus revealed the decrease of NAA/Cr ratio in the heroin -dependent patients, which was significant difference in comparison with the normal controls（ P 〈 0. 05 ） , but the Cho/Cr ratio had no significant difference between this two groups. Conclusion ^1H MRS can reveal the early damage of the neuronal function of hippoeampus in heroin - dependent patients,but without the morphologie changes being found.

关 键 词：脑 海洛因 磁共振波谱分析 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R996[医药卫生—基础医学]