子宫腺肌症雌激素受体、孕激素受体与bcl-2的表达  

Expressions of estrogen receptor, progesterone receptor and bcl-2 in adenomyosis uterus

作　　者：廖谦和[1] 胡树红[2] 陈利琼[2] 吴文珍[1] 阮荣和[1] 蔡宇清[2] 夏康[1] 

机构地区：[1]温州医学院附属第三医院病理科,瑞安325200 [2]温州医学院附属第三医院妇产科,瑞安325200

出　　处：《临床与实验病理学杂志》2006年第6期663-665,共3页Chinese Journal of Clinical and Experimental Pathology

基　　金：浙江省温州市科技局医药卫生科技计划项目(Y2005A179)

摘　　要：目的探讨雌激素受体(ER)、孕激素受体(PR)和bcl-2在子宫腺肌症中异位和在位内膜的表达及意义。方法用免疫组化EnVision法检测40例子宫腺肌症在位子宫内膜和肌间异位内膜ER、PR和bcl-2的表达情况。结果在位和异位子宫内膜组织中均有ER、PR和bcl-2的阳性表达。其中腺上皮阳性表达率高于间质(P<0.05),且异位内膜的腺上皮bcl-2阳性表达率高于在位组织(P<0.05);ER和PR的表达两者差异无显著性(P>0.05)。异位内膜腺体ER、PR与bcl-2表达具有相关性(P<0.01)。结论子宫腺肌症异位和在位子宫内膜组织中均有ER、PR和bcl-2的阳性表达,可能与子宫腺肌症的发生、发展有关。Purpose To investigate the expressions of ER, PR and bcl-2 in the pathogenesis of adenomyosis uterus. Methods The expressions of ER, PR and bcl-2 in 40 cases of adenomyosis uterus were detected by immunohistochemical EnVision method. Results Both the eutopic and ectopic endometrium in 40 cases showed positive for ER, PR and bcl-2 （P 〉 0.05）. The strong positive rate in the eutopic endometrium was significantly higher than that in the stroma cells （ P 〈 0. 05 ）. The expression of bcl-2 increased significantly in ectopic endometrium was slightly than those in eutopic endometrium （ P 〈 0.05）. The expression of ER and PR had a positive correlation with the expression of bcl-2 （P 〈 0.01 ）. Conclusions ER, PR and bcl-2 may play an important roles in promoting the development of adenomyosis.

关 键 词：子宫疾病 子宫腺肌症 雌激素受体 孕激素受体 BCL-2 免疫组织化学 

分 类 号：R711.74[医药卫生—妇产科学]