透明颤菌血红蛋白的应用进展  

Application Progress of Vitreoscilla Hemoglobin

作　　者：袁宁[1] 胡又佳[1] 朱春宝[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国生物工程杂志》2006年第12期107-111,共5页China Biotechnology

基　　金：国家"863"计划资助项目(2004AA214160)

摘　　要：透明颤菌血红蛋白(VHb)具有在限氧条件下促进异源宿主细胞生长和增加产物产量的作用,已在发酵、环保、转基因动植物、重组蛋白表达等方面得到了广泛应用。将VHb与酶或蛋白融合表达可提高酶的活性、稳定性或蛋白的分离效率。对VHb进行改造有助于获得性能更良好的“新”蛋白。Vitreoscilla Hemoglobin （VHb）, with the function of increasing the growth of and product yield by a heterologous host, has been widely use in the area of fermentation, environment protection, transgenic animal and plant, recombinant protein expression, etc. Fusion protein of VHb with other enzyme or protein can enhance activity and stability of the enzyme or isolation efficiency of the protein. The reconstitution of VHb will be helpful to obtain ‘novel＇ proteins which have better activity.

关 键 词：透明颤菌血红蛋白 VHB 融合蛋白 

分 类 号：Q819[生物学—生物工程]