卡维地洛对心衰大鼠心肌细胞间粘附分子-1表达的影响  

Effect of Carvedilol on Expression of ICAM-1 during Heart Failure Subsequent to Myocardial Infarction in Rats

作　　者：吴强[1] 李隆贵[2] 蔡运昌[1] 杨天和[1] 王晓峰[1] 耿召华[2] 

机构地区：[1]贵州省人民医院心内科,贵阳550002 [2]第三军医大学附属新桥医院心内科,重庆400037

出　　处：《中国分子心脏病学杂志》2002年第5期21-24,共4页Molecular Cardiology of China

基　　金：贵州省科学技术基金(No.3044)

摘　　要：目的 观察心肌梗死后心力衰竭大鼠心肌细胞间粘附分子-1(ICAM-1)表达的改变及卡维地洛干预的影响。方法:将雄性Waistar大鼠前降支结扎,于术后1周开始予卡维地洛、美托洛尔及特拉唑-嗪干预7周,观察三种三种肾上腺素能受体阻滞剂对大鼠心肌核因子-κB(NF-κB)的核结合活性、心肌ICAM-1的mRNA和蛋白表达的影响。结果:心肌梗死后8周大鼠心肌NF-κB活性增高,ICAM-1的mRNA和蛋白表达增强,卡维地洛可明显降低NF-κB的活性和ICAM-1的表达,而美托洛尔和特拉唑嗪对NF-κB活性和ICAM-1的表达无明显影响。结论:心肌细胞ICAM-1表达上调在心肌梗死后心力衰竭的病理生理机制中具有重要的作用,卡维地洛可明显抑制MI大鼠心肌ICAM-1的表达,这可能与其抑制NF-κB激活有关。Objective To study the effect of carvedilol on the expression of intercellular adhesion molecule-1 （ICAM-1） during heart failure subsequent to myocardial infarction in rats. Methods Using a animal model of myocardial infarction （MI）, induced by the left coronary artery ligation in male waistar rats, the nuclear DNA binding activity of NF-κB and the expression of ICAM-1 were investigated in the untreated experimental group （MI group） at 8-week after operation and treated experimental groups in which rats were treated with carvedilol （CAR group）, metoprolol （MET group） and terazosin （TER group） for 7 weeks since 1 week after operation. Results The activity of NF-κB, the myocardial levels of mRNA and protein of ICAM-1 were markedly higher in the MI group, MET group and TER group than those in CAR group. Conclusion The upregulated expression of ICAM-1 may play an important role in the pathogenesis of heart failure subsequent to myocardial infarction. Carvedilol can effectively decrease ICAM-1 expression by inhibiting the activation of NF-κB during heart failure subsequent to myocardial infarction in rats.

关 键 词：细胞间粘附分子-1 卡维地洛 核因子-ΚB 心力衰竭 心肌梗死 

分 类 号：R541.6[医药卫生—心血管疾病]