山羊心房颤动进展过程中肺静脉与左房电生理变化的比较  

Electrophysiological changes in pulmonary vein and left atrium in the development of persistent atrial fibrillation in goat model.

作　　者：周俊彦[1] 王玉堂[1] 单兆亮[1] 时向民[1] 闫俊瑾[1] 国建萍[1] 王卫华[1] 

机构地区：[1]解放军总医院心内科,北京100853

出　　处：《中国心脏起搏与心电生理杂志》2006年第6期523-525,共3页Chinese Journal of Cardiac Pacing and Electrophysiology

摘　　要：目的比较山羊心房颤动（简称房颤）进展过程中肺静脉与左房电生理变化的差异。方法在12只山羊的左房游离壁及左上肺静脉外膜缝合电极片，心房快速刺激，诱发维持时间超过24h的持续性房颤。定期终止刺激，测量不同基础起搏周长时的左房及肺静脉的有效不应期（ERP），同时记录在测量ERP时的房颤诱发情况。结果9只山羊完成实验，均在5-14d内诱发出持续性房颤。基础状态下左房和肺静脉的ERP无显著差异；随着刺激时间的延长，ERP均逐渐缩短（P〈0．05），并出现ERP频率适应性丧失，但两者间无显著差异；随着房颤持续时间的延长，肺静脉与左房的房颤诱发率逐渐增高（P〈0．05），但两者之间无显著性差异。结论在房颤进展过程中，肺静脉和左房ERP缩短，房颤诱发率增高，但两者无明显差异。Objective To compare the changes of electrophysiological parameters in pulmonary vein （PV） and left atrium （LA） in goat model of persistent atrial fibrillation （AF）. Methods Twelve female goats were instrumented with epicardial electrodes patches on the left atrium （LA） and left superior pulmonary vein （LSPV）. AF was induced and maintained by atrial stimulator. The effective refractory period （ERP） and the inducibility of AF were measured in LSPV and LA regularly. Results Persistent AF could be induced in the 9 goats within 5-14 days. In baseline, there was no significant difference in ERP between LSPV and LA. With the perpetuation of AF, ERP shortened and rate adaptability decreased gradually （P 〈0.05 ）. But there was no significant difference between LSPV and LA. The inducibility of AF in LSPV and LA increased gradually （P 〈0.05 ）. It showed no significant difference between LSPV and LA. Conclusion The electrophysiological changes in LSPV are comparable to those in LA in the process of electrical remodeling. It shows no significant difference in the inducement of AF between LSPV and LA in this model.

关 键 词：电生理学 心房颤动 肺静脉 左房 有效不应期 山羊 

分 类 号：R331.38[医药卫生—人体生理学] R541.75[医药卫生—基础医学]