铅对大脑海马第1、3信使系统的影响  

The Effects of Lead on Primary and Tertiary Messengers in Brain Hippocampus

作　　者：傅雪[1] 姜岳明[1] 胡万达[1] 

机构地区：[1]广西医科大学劳动卫生学与毒理学教研室,广西南宁530021

出　　处：《铁道劳动安全卫生与环保》2006年第6期305-308,共4页Railway Occupational Safety Health & Environmental Protection

摘　　要：铅(Pb)是环境中常见的一种亲神经毒物。随着Pb的广泛应用,人体接触Pb机会随之增多。长期低水平Pb暴露、蓄积以及过量吸收,可在细胞水平、细胞内水平以及分子水平上对神经系统产生一系列的毒性作用。Pb可选择性地蓄积在大脑海马,并引起一系列的病理生理改变,如海马神经元凋亡、长时程增强(LTP)改变、影响神经递质释放和基因表达调控等,从而影响学习记忆功能。Pb可以在不同的调控水平,包括海马第1、2、3信使系统,产生广泛的生物学效应,可导致神经细胞凋亡、智力、记忆力、神经行为障碍。Superfluous absorption of lead such as cellular level, intracellular level and may produce a series of toxicities to neural system in several levels molecular level. It is necessary to study the toxicities of lead upon hippocampus in different regulative levels for the toxicities have consanguineous correlations with studying, memorizing and nerval behavior, etc. Here, we make a review about the effect of lead upon primary messenger （nerval transmitter and NMDAR） and tertiary messenger （expressions of immediate early response gene such as fos, jun and bcl-2, etc）.

关 键 词：铅 海马 神经递质 NMDAR 基因表达 

分 类 号：R135.1[医药卫生—劳动卫生]