益肝灵分散片溶出度的研究  

Study on Dissolution content from Yi-Gan-Ling Dispersible Tablets

作　　者：李光锋[1] 饶力群[1] 彭国平[1] 

机构地区：[1]湖南农业大学生物科学技术学院

出　　处：《中医药导报》2006年第12期72-73,86,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:建立益肝灵分散片溶出度的测定方法,为质量控制提供方法和参数。方法:以磷酸盐缓冲液为溶出介质,转速为75转/m in,照分光光度法在288 nm处测定吸收度,计算每片的溶出量。结果:3批益肝灵分散片的溶出度基本一致,45 m in累积百分溶出总量均能达到《中国药典》2005年版中规定的释放标示量的70%,重复性良好。结论:益肝灵分散片质量能达到《中国药典》2005年版要求,且分散片的溶出速度明显快于市售片。Objective： To establish a method to determine the dissolution of Yi - Gan - Ling Dispersible Tablets for evaluating and controlling the drug quality. Method： The absorbance was measured by spectrophotometric determination in 288nm according to Chinese Pharmacopoeia （2005 Edition） methods in phosphate buffer with rotating speed by 75r/min and calculated dissolution content per tablet. Result： The content detected equally from three groups of Yi - Gan - Ling Dispersible Tablets that dissolved in the same time, the accumulative content dissolved for 45 minutes was accorded with the releasing standard of labeled amount of Chinese pharmacopoeia （2005 Edition） and had a good repeat. Conclusion： The quality is accorded with the standard of Chinese Pharmacopoeia （2005 Edition） and the dissolved speed of dispersible tablets is faster than the tablets on sale.

关 键 词：益肝灵 分散片 水飞蓟宾 溶出度 

分 类 号：R927.2[医药卫生—药学]