老年原发性高血压患者β_2肾上腺素受体基因Arg16Gly多态性研究  

Study of β_2-adrenergic Receptor Gene Arg16Gly Polymorphism in Elder Essential Hypertension

作　　者：王娜[1] 王志[1] 

机构地区：[1]北京博爱医院急诊科,北京市100068

出　　处：《中国康复理论与实践》2006年第10期905-907,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨老年人(≥60岁)β2肾上腺素受体(β2-AR)基因Arg16Gly多态性与高血压病的关系。方法随机抽取115名无血缘关系的老年原发性高血压患者(EH)为病例组,150名无血缘关系的健康老年人为对照组,采用PCR扩增技术测定两组对象的β2-AR基因型。结果高血压组的Arg/Arg、Gly/Gly和Arg/Gly基因型频率分别为22.81%、53.51%和23.68%;对照组分别为27.33%、67.33%和5.33%,两组间有显著性差异(P<0.05)。Arg和Gly的等位基因频率高血压组为49.56%、50.44%;对照组为61.00%和39.00%,两组间亦有显著性差异(P<0.05),但两组的Arg/Gly多态性分布均符合Hardy-Weinberg定律。结论本研究对象的β2-AR基因多态性可能与原发性高血压有关。Objective To explore the relationship between β2adrenergie receptor （β2AR） gene Argl6Gly polymorphism and essential hypertension （EH） in elder （≥60 years old）. Methods 150 old healthy controls and 115 old patients with EH （all of them without kin relation） were selected to test genotype of β2-AR by the technique of polymerase chain reaction restriction fragment length polymorphism （PCR-PFLP）. Results The frequencies of three genotypes （Arg/Arg, Arg/Gly and Gly/Gly） were 22. 81%, 53.51% and 23.68% in the EH group and 27.33%, 67.33% and 5. 33% in the controls respectively. The frequencies of Arg and Gly allele were 49.56% and 50.44% in the EH group, and 61.00% and 39.00% in the controls. There was a significant difference in distribution of alleles/genotypes between EH group and controls （ P 〈20.05）. Conclusion β2-AR Arg16Gly gene polymorphism is possibly associated with hypertension in this study population.

关 键 词：原发性高血压 Β2肾上腺素受体 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]