清毒汤对大鼠实验性肝损伤内毒素血症的治疗作用  

Experimental study of effect of Qingdu decoction on hepatic injuries by endotoxin in rats

作　　者：高连印[1] 杜宇琼[1] 付修文[1] 车念聪[1] 王融冰[2] 

机构地区：[1]首都医科大学中医药学院中医临床基础教研室,北京100069 [2]北京地坛医院

出　　处：《中西医结合肝病杂志》2006年第6期347-349,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：北京市中医药管理局资助项目(No.JJ2003-3)

摘　　要：目的:探讨清毒汤对大鼠肝损伤内毒素血症的作用机制。方法:建立硫代乙酰胺(TAA)所致大鼠肝损伤内毒素血症模型,以清毒汤进行干预,通过血液生化及病理检查,观察其对内毒素血症大鼠肝功能、肿瘤坏死因子、内毒素的影响。结果:清毒汤能明显降低肿瘤坏死因子(TNF-α)、内毒素的含量,减轻肝细胞坏死程度,与模型组比较差异有显著性意义(P<0.05,P<0.01)。结论:清毒汤能使内毒素含量、TNF-α水平降低是其对TAA所致大鼠肝损伤具有防护作用的机制之一。Objective： To study the therapeutic effect and mechanism of Qingdu Decoction on hepatiic injures by endotoxin in rats. Methods： Endotoxemia model of Wistar rats was made by thioacetamide. Blood biochemistry and pathological changes were examined to observe the effect of Qingdu decoction on liver function, TNF-α, Endotoxin of the model rats. Results： Qingdu decoction could reduce the contents of ALT, AST, TNF-α, endotoxin in the blood and the degree of hepatic cells necrosis of Wister rats. There was significant difference as compard with model group （ P 〈 0. 05, P 〈 0.01 ） . Conclusion ： Qingdu decoction has better effect in the treatment of intestinal endotoxemia.

关 键 词：清毒汤/药效学 内毒素血症 大鼠 

分 类 号：R285.5[医药卫生—中药学]