2型糖尿病患者血清骨钙素与碱性磷酸酶的相关性分析  

The correlation between serum osteocalcin and alkaline phosphate in type 2 diabetic patients.

作　　者：崔裕祥[1] 陈慧[1] 倪安民[1] 张宏刚[1] 李兰英[1] 

机构地区：[1]兰州大学第二医院内分泌科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2006年第4期23-25,共3页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的了解2型糖尿病患者的血清骨钙素(BGP)和碱性磷酸酶(AKP)的关系。方法测定55例2型糖尿病患者(肾病25例,非肾病30例)和27例正常人血清BGP、AKP及骨型AKP活性分析。结果两组糖尿病患者的BGP明显降低,血清AKP显著升高,两者间无相关关系,骨型AKP活性无显著性差异(P＞0．05)。结论2型糖尿病患者骨形成降低,呈低转换型骨代谢,BGP可准确反映骨形成和骨转换,且明显优于AKP。Objective In an attempt to evaluate effects of blood glucose level on bone mineral metabolism in type 2 diabetic patients. Methods 55 diabetic patients（including 25 patients accompanying nephropathy） and 27 normal controls were studied. Results Compared with the normal controls, the patients demonstrated a decrease in serum osteocalcin（BGP） and a rise in serum alkaline phosphatase（AKP）. The concentration of BGP had not a negative correlation with that of AKP（r = -0.1, P 〈0.37）. Conclusion It is suggested that diabetic osteoporosis is part of lower turnover and its growth is obviously arrested.

关 键 词：2型糖尿病 骨钙索 碱性磷酸酶 

分 类 号：R587.1[医药卫生—内分泌]