儿童咳嗽变异性哮喘与肺炎支原体感染关系探讨  被引量:5

Relationships between children's cough variant asthma and pneumonia mycoplasma infection

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作  者:方玫[1] 詹娜萍[1] 

机构地区:[1]厦门市第二医院儿科,福建厦门361026

出  处:《兰州大学学报(医学版)》2006年第4期55-57,共3页Journal of Lanzhou University(Medical Sciences)

摘  要:目的探讨儿童咳嗽变异性哮喘(CVA)与肺炎支原体感染的关系。方法CVA病例93例,上呼吸道感染病例104例,进行血清肺炎支原体IgM(MP-IgM)测定,对CVA病例中MP-IgM阳性30例随机分为两组:对照组仅给予糖皮质激素和支气管扩张剂吸入,治疗组吸入同时给予阿奇霉素或红霉素治疗;观察日夜咳嗽和睡眠情况,并进行评分。结果普通上呼吸道感染病例中肺炎支原体感染率为11.52%,而CVA患者中肺炎支原体感染率达32.25%,两组患儿比较有显著性差异(P<0.01)。与对照组比较,MP-IgM阳性CVA患儿经糖皮质激素及支气管扩张剂吸入+抗菌素治疗后,咳嗽及睡眠情况明显改善,咳嗽发作间期明显延长(P<0.01)。结论CVA患儿肺炎支原体感染率明显高于对照组.提示肺炎支原体是小儿呼吸道感染的常见病原,并与CVA的发作有密切关系。应用阿奇霉素或红霉素治疗可改善伴有肺炎支原体感染CVA患儿的症状。Objective To study the relationships between children's cough variant asthma(CVA) and pneumonia mycoplasma infection. Methods Pneumonia mycoplasma IgM(MP-IgM) was dctccted in 93 cases of CVA patients and 104 cases of upper respiratory tract infection. 30 MP- IgM positive cases with CVA were divided randomly into two groups: treatment group(n=15) and control group(n=15). Inhaled steroids and bronchodilators were given to all cases of the two groups, and azithromycin or erythromycin was given only to cases in treatment group. The day/night cough and sleep status were counted everyday. Results The pneumonia mycoplasmal infectious rates in CVA patient and upper respiratory tract infection patients were 32.25% and 11.52% respectively(P 〈: 0.01). In MP-IgM positive CVA patients, the cough and sleep status in treatment group significantly improved than in control group(P 〈 0.01). Conclusion Pneumonia mycoplasma infectious rates in children's CVA patients were significantly higher than that in upper respiratory tract infection patients. It is suggested that pneumonia mycoplasma infections connect with CVA attack, and azithromycin or erythromycin may improve the symptoms of CVA patients with pneumonia mycoplasma infection.

关 键 词:咳嗽变异性哮喘 肺炎支原体 儿童 

分 类 号:R725.6[医药卫生—儿科]

 

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