两种输液分别配伍六个厂家头孢哌酮钠后的质量考察  

Study the quality of two fusions matched cefoperazone sodium for injection from six pharmaceutical factories

作　　者：李莉[1] 李建凯[1] 米清优 赵元文 

机构地区：[1]长庆石油勘探局职工总医院,甘肃庆阳745101

出　　处：《中国现代应用药学》2006年第6期498-500,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的考察输液中加入注射用头孢哌酮钠(Cefoperazone Sod ium for In jection)后输液质量的差异。方法利用药典规定的方法,对输液中加入头孢哌酮钠前及加入后不同放置时间进行不溶性微粒等项目的测定。结果六个厂家注射用头孢哌酮钠配伍两种输液后,输液的pH在规定范围内,输液中头孢哌酮钠的含量在测定时间范围内变化不大,但不溶性微粒存在超标问题。温度和pH是影响头孢哌酮钠溶解性的主要因素,头孢哌酮钠的溶解时间差异较大。结论从头孢哌酮钠的溶解时间和输液不溶性微粒的情况来看,推荐临床使用C或F。OBJECTIVE To compare the quality of infusions matched cefoperazone sodium for injection among six pharmaceutical factories. METHODS The change in particulate matter and pH of infusions and contents of eefoperazone sodium for injection were determined by the method of pharmacopeia. RESULTS The superstandard problem of the numbers of particulate matter existed in dif- ferent degree, the pH of infusions was qualified, there were not obviously difference in contents of cefoperazone sodium for injection in fusion when eefoperazone sodium for injection was dissolved in 0.9% sodium chloride injection or 5% glucose sodium chloride injection. Temperature and pH are important elements in these dissolving phases. There were much difference in the dissolved time among six pharmaceutical factories. CONCLUSION It is suggested that C or F might be used better in clinical according to the dissolved time of Cefoperazone Sodium for Injection and the particulate matter in fusion in this experiment.

关 键 词：注射用头孢哌酮钠 不溶性微粒 溶解时间 

分 类 号：R927.11[医药卫生—药学]