养肝柔筋方对运动性中枢疲劳大鼠血、脑游离色氨酸和脑5-羟色胺含量的影响  

Influnence of Yangan Roujin Prescription on F-Trp and 5-HT Levels of Blood and Brain in Exercise-induced Central Fatigue Rats

作　　者：王芳[1] 史丽萍[1] 马佐英[1] 何山[2] 毕慧娟[1] 

机构地区：[1]天津中医药大学,300193 [2]天津市开发区医院,300357

出　　处：《天津中医药大学学报》2006年第4期222-224,共3页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：天津市教委资助课题(20040326)

摘　　要：[目的]研究养肝柔筋方在运动性中枢疲劳中的作用及其机制。[方法]将养肝柔筋方用于游泳训练造成的运动性中枢疲劳模型上,并与训练组对照观察其对模型动物血中游离脂肪酸(FFA)、游离色氨酸/支链氨基酸(F-Trp/BCAA)比值的变化,及脑中游离色氨酸(F-Trp)、5-羟色胺(5-HT)和5-羟吲哚乙酸(5-HIAA)的含量的影响。[结果]与训练对照组相比,训练中药组大鼠血中FFA、BCAA的含量呈升高趋势,脑中F-Trp含量显著降低。[结论]提示养肝柔筋方可能在一定程度上提高或稳定运动机体内FFA、BCAA的浓度,改变血脑屏障的渗透性,降低大脑对F-Trp的摄取,延缓中枢疲劳的发生。[Objective] To explore the effect of Yanggan Roujin Prescription（YGRJF） on eliminating exercise-induced central fatigue. [Methods] Using YGRJF on rat model of swimming training-induced central fatigue, observed the changes on the content of plasma FFA and the ratio of F-Trp /BCAA, the levels of brain tissue F-Trp, 5-Htand and 5-HIAA in central fatigue rat. [Results] Compared with the training rats in control group, in the training group ingesting YGRJF the content of plasma FFA and BCAA have the upward trend, but the content of brain tissue F-Trp obviousely down regulate. [Conclusion] YGRJF can chang osmosis of blood-brain barrier and stave off the central fatigue occurrence by stabilizing the concentration of plasma FFA and BCAA to a certain extent, reducing the ingestion of brain F-Trp.

关 键 词：养肝柔筋方 游离色氨酸 支链氨基酸 5-羟色胺 运动性中枢疲劳 

分 类 号：R285.5[医药卫生—中药学]