多孔磷酸三钙与自体红骨髓复合移植修复骨缺损的临床应用  

CLINICAL APPLICATION OF POROUS TRICALCIUM PHOSPHATE CERAMIC COMBINED WITH AUTOGENOUS RED MARROW IN REPAIR OF BONE DEFECTS/

作　　者：郑承泽[1,2] 苏国礼[1,2] 王天兵[1,2] 李文胜 黄忠录[1,2] 

机构地区：[1]汕头大学医学院第一附属医院骨科 [2]上海第二医科大学新华医院成人骨科

出　　处：《中国修复重建外科杂志》1996年第3期164-167,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：为观察多孔磷酸三钙（ｔｒｉｃａｌｃｉｕｍｐｈｏｓｐｈａｔｅ，ＴＣＰ）与自体红骨髓（ｂｏｎｅ－ｍａｒｒｏｗ，ＢＭ）复合移植修复骨缺损的临床应用效果，应用ＴＣＰ－ＢＭ复合移植，修复骨缺损２１例，其中肿瘤性骨缺损１７例，陈旧性骨折骨缺损４例。术后定期拍摄Ｘ线片复查。术后６周，植入人工骨与周围骨组织界面间已有明显新骨形成；术后３个月，植入材料与周围骨组织愈合成一体。随访１～３年，结果显示植入材料的成骨作用明显，效果满意。ＴＣＰ－ＢＭ具有骨传导和骨诱导双重成骨作用，能促进新骨形成和加快骨缺损修复。To examine the effects of porous tricalcium phosphate (TCP) combined with autogenous red bone marrow (BM) in the repair of bone defects, 21 cases of bone defects were implanted with the above prepared composite material, 17 cases had benign or low grade malignant tumors and 4 cases had old fractures. Serial X ray films were taken after surgery. The results showed that new bone formation was seen between the interface of the implant and surrounding host bone after 6 weeks, and osseous union developed after 12 weeks. Evident osteogenesis in all patients was observed after a follow up for 1～3 years. TCP BM is both osteoconductive and osteoinductive. Its function was similar to the fresh autogenous cancellous bone graft and TCP BM had the potency of promoting the repair of osseous defect. It was suggested that TCP BM might be an ideal material for treating bone defects.

关 键 词：骨缺损 磷酸古钙 红骨髓 复合移植 

分 类 号：R683.05[医药卫生—骨科学]