新型络合剂MeOBGDTC对亚慢性镉中毒大鼠驱镉效果的研究  

The Effect of MeOBGDTC on the Excretion of Cadmium in Rats with Subchronic Cadmium Poisoning

作　　者：张久松 徐兆发 丁桂英 李革新 

出　　处：《中国医科大学学报》1996年第5期476-478,共3页Journal of China Medical University

基　　金：辽宁省科委重点科研基金

摘　　要：通过亚慢性动物实验研究了新型络合剂４－甲氧苄基－Ｄ－葡糖胺－Ｎ－二硫代羧酸钠（ＭｅＯＢＧＤＴＣ）对尿镉排泄及组织脏器中镉含量的影响。先给大鼠腹腔注射４．４４８μｍｏｌＣｄ２＋／ｋｇｄ的氯化镉，每周５次，共４周。然后腹腔注射８８９．６００μｍｏｌ／ｋｇｄ的ＭｅＯＢＧＤＴＣ，每周５次，间隔１周为１个疗程，共两个疗程。结果表明：能显著增加大鼠的尿镉排泄量，且可持续至第１０个给药日，分别是单纯染镉组的１．４０～３．３３倍。尿镉排泄水平随给药次数的增加而逐渐降低。ＭｅＯＢＧＤＴＣ还能明显降低大鼠血液及肝、肾等组织中的镉负荷。The effect of Sodium N 4 methoxybenzyl D glucamine N carbodithioate(MeOBGDTC), a new chelating agent,on the excretion of cadmium in various tissues was investigated in rats with subchronic poisoning. First,cadmium chloride was administered intraperitoneally(i.p) with a dose of 4.448 μmol/kg·day 5 times per week for 4 weeks. Then rats were given MeOBGDTC(889.600 μmol/kg·day,ip), 5 times per week as the first course. With an inteval of one week the second course began. The results showed that MeOBGDTC increased the urinary excretion of cadmium significantly.On the tenth day of treatment,the excretion of cadmium in test group was 1.04 to 3.33 times as much as in control group.MeOBGDTC also decreased the load of cadmium in blood, liver and kidney obviously.

关 键 词：二硫代羧酸钠 镉中毒 

分 类 号：R595.2[医药卫生—内科学] R598.1[医药卫生—临床医学]