血管内皮生长因子:从血管形成到神经元保护  

Vascular endothelial growth factor: from angiogenesis to neuroprotection

作　　者：顾卫东[1] 薛庆生[1] 于布为[1] 

机构地区：[1]上海交通大学医学院瑞金医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2006年第6期354-356,共3页International Journal of Anesthesiology and Resuscitation

基　　金：上海交通大学医学院博士学科点建设基金资助项目(项目编号:BXJ0612)

摘　　要：Vascular endothelial growth factor(VEGF),a highly conserved heparin-binding protein,was found originally in vascular endothelial cells and showed a high potency for angiogenesis and endothelial proliferation.VEGF can induce collateral growth in the ischemic tissue and therefore,is used in the treatment of ischemic vascular disease.Recently,Endogenous expression of VEGF mRNA and VEGF has been observed in neuronal cells,and its expression is up-regulated by ischemia-reperfusion.Besides its role on angiogenesis,recent evidence indicates that VEGF can also act directly on neurons to produce neurotrophic and neuroprotective effects.Vascular endothelial growth factor （VEGF）, a highly conserved heparin-binding protein, was found originally in vascular endothelial cells and showed a high potency for angiogenesis and endothelial proliferation. VEGF can induce collateral growth in the ischemic tissue and therefore, is used in the treatment of ischemic vascular disease. Recently, Endogenous expression of VEGF mRNA and VEGF has been observed in neuronal cells, and its expression is up - regulated by ischemia - reperfusion. Besides its role on angiogenesis, recent evidence indicates that VEGF can also act directly on neurons to produce neurotrophic and neuroprotective effects.

关 键 词：血管内皮生长因子 神经元保护作用 血管形成 缺血性血管疾病 内皮细胞增殖 缺血性心肌病 中枢神经组织 VEGF 

分 类 号：R341[医药卫生—基础医学]