深圳妇女人乳头瘤病毒的型别分布  

Distribution of Human Papillomavirus Types in Shenzhen Women

作　　者：石菊芳[1] 吴瑞芳[2] 刘植华[3] 周庆芝[4] 李霓[5] 乌兰娜[6] 李晴[3] 王倩[4] 刘彬[5] 李瑞珍[6] 乔友林[5] 

机构地区：[1]山西医科大学流行病学教研室 [2]Centre of Early Diagnosis and Early Treatment for Cervical Carcinoma,Shenzhen Hospital of Peking University,Shenzhen 518036 [3]Department of Gynecology,Shenzhen City Maternity and Child Health Hospital,Shenzhen 518028 [4]Population and Family Plan-ning Bureau of Nanshan District,Shenzhen 518052 [5]Department of Cancer Epidemiology,Cancer Institute,CAMS and PUMC, Beijing 100021 [6]Centre of Early Diagnosis and Early Treatment for Cervical Carcinoma, Shenzhen Hospital of Peking University,Shenzhen 518036

出　　处：《中国医学科学院学报》2006年第6期832-836,共5页Acta Academiae Medicinae Sinicae

基　　金：世界卫生组织国际癌症研究所(ICE/92/3-3CHN);高等学校博士学科点专项科研基金(20030023014)~~

摘　　要：目的 调查深圳市妇女生殖道不同型别人乳头瘤病毒（HPV）的感染状况以及在人群中的分布。方法 采用整群分层的抽样方法对深圳市南山区华侨城社区15—59岁的女性开展以人群为基础的宫颈癌筛查。签署知情同意书后，对合格对象进行流行病学问卷调查。采集受试者宫颈脱落细胞，进行液基细胞学检测、HPV-DNA的第2代杂交捕获（hc2）试验和HPV分型基因芯片检测。结果 共1137名妇女入选。hc2和基因芯片对13种高危型HPV的检出率分别为14．0％和9．8％，前者检出率显著高于后者（Х^2=27．198，P〈0．001），两种方法一致性较好（kappa=0．498，P〈0．001）。基因芯片对低危型和其他型别HPV的检出率分别为1．9％和0．2％。高危型HPV阳性人群中16、18和58型HPV百分比依次为29．7％、18．9％和18．9％。低危型HPV的年龄别人群检出率（17—34、35—44和45—59岁）依次为1．4％、1．7％和3．2％。结论 16、18和58型为该人群最常见的3种高危型HPV，高危型HPV的年龄别感染率差别主要表现为HPV16在人群中的变化。低危型HPV的感染机会随年龄的增大而增大。Objective To investigate the status of genital infection as well as distribution of types of human papillomavirus （HPV） in women in Shenzhen and provide population data for the future vaccine intervention on cervical cancer. Methods Women with age between 15 and 59 years were selected in cluster stratified sampling from Huaqiaocheng community, Nanshan district, Shenzhen and received a population-based cervical cancer screening. After consent, every woman was interviewed by using questionnaire and tested by liquid-based cytology and HPV DNA （hybrid capture 2 and gene chips typing） separately. Results Totally 1 137 women were screened. The rate of high risk HPV of hybrid capture 2 test （ 14. 0% ） was higher than gene chips typing test （9. 8% ） （ Х^2 = 27. 198, P 〈 0. 001 ） ; the consistence of the two tests was acceptable （ kappa = 0. 498, P 〈0. 001 ）. The rates of low risk HPV types and other types of gene chips typing test in this population were 1.9% and 0. 2% respectively. The percentages of HPV 16, 18 and 58 in HPV positive women were 29.7%, 18.9% and 18.9%. The rates of different age group of low risk HPV were 1.4% （17-34）, 1.7% （35- 44） and 3.2% （45-59）, respectively. Conclusions HPV 16, 18, and 58 are the most popular types in the study population. The differences of infection rates of high risk HPV are due primarily to the variation of HPV16 distribution among age-specific population. The chances of being affected by low risk HPV will increase with age.

关 键 词：人乳头瘤病毒 分型 分布 宫颈癌 

分 类 号：R373[医药卫生—病原生物学] R181[医药卫生—基础医学]