新型天然杀螨药物樟脑精油的杀螨效果观察与机制分析  

The effect and mechanism of new natural miticide camphor oil in killing Demodex

作　　者：赵亚娥[1] 郭娜[1] 师睿[1] 张灵小[1] 

机构地区：[1]西安交通大学医学院免疫学与病原生物学系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2006年第6期544-547,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省自然科学基金资助项目(No.2004C230)

摘　　要：目的观察樟脑精油对两种人体蠕形螨的体外杀灭效果,分析其杀螨机制。方法采用透明胶带粘贴法获取蠕形螨,随机分为六组,观察不同浓度下樟脑精油的杀虫作用,并在Motic DM图像采集软件系统下观察虫体对樟脑精油的药物反应过程。结果樟脑精油对两种蠕形螨均有杀灭作用,对皮脂蠕形螨的杀灭作用要强于毛囊蠕形螨,且杀虫效果随着药物浓度的增加及作用时间的延长而增强。12.5%樟脑精油是体外杀螨的最适浓度。显微镜下观察可见,使用樟脑油后,螨虫在经历短时间的兴奋痉挛期后,虫体松弛、死亡。结论樟脑精油具有良好的体外抗蠕形螨的作用,其机制可能是通过直接触杀作用和神经肌肉毒性作用完成的。Objective To study the effect of camphor oil in killing Demodex in vitro and to further analyze the killing mechanism. Methods The mites were collected with adhesive cellophane tape and randomly divided into six groups. The killing effect of camphor oil was investigated with different concentrations against Demodex in vitro. The reaction progress was pictured using Motic Images software. Results Camphor oil had better killing effect on Demodex folliculorum than on D. brevis in vitro. The death rate increased with the drug concentration and time. The most suitable and effective concentration of killing both Demodex folliculorum and D. brevis in vitro was 12.5%. After the drug was given, the mites contracted and twisted, and then relaxed and died. Conclusion Camphor oil has strong killing effect on Demodex in vitro. The main mechanism of camphor oil may be related to direct contact and neuromuscular toxicity.

关 键 词：樟脑油 毛囊蠕形螨 皮脂蠕形螨 杀灭作用 

分 类 号：R384.4[医药卫生—医学寄生虫学]