长托宁治疗急性有机磷农药中毒的临床观察  

Clinical observation of the effects of long-acting Tuoning in the treatment of acute organophosphorus pesticide poisoning

作　　者：南佳彦[1] 高小雁[2] 李惠玲[1] 杨继维[1] 

机构地区：[1]西安交通大学医学院第一附属医院急诊科,陕西西安710061 [2]西安交通大学医学院公共卫生学系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2006年第6期622-624,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的观察长托宁与阿托品治疗急性有机磷农药中毒(AOPP)的临床效果。方法97例急性有机磷农药中毒的患者随机分为长托宁组(50人)与阿托品组(47人),长托宁组用长托宁配合氯磷定治疗,阿托品组用阿托品配合氯磷定治疗,对疗效进行比较。结果长托宁可使有机磷中毒患者的中毒症状持续的时间缩短(两组间M样症状消失时间分别为1.2 h和5.0 h,有显著性差异,P<0.05),治愈率提高,死亡率减少(长托宁组分别为98%、2%,阿托品组分别为80.75%、19.15%),阿托品中毒人数减少(长托宁组3人、阿托品组14人),因阿托品中毒死亡率减少(长托宁组0、阿托品组17%),患者住院平均日缩短(长托宁组4-5 d、阿托品组7-10 d)。结论长托宁目前是救治急性有机磷农药中毒最理想的抗胆碱药。Objective To observe the effects of long-acting Tuoning and atropine in the treatment of acute organophosphorus pesticide poisoning （AOPP）. Methods A total of 97 cases of AOPP were randomly divided into therapy group （n = 50） and control group （n =47）. Therapy group were treated with long-acting Tuoning combined with pyraloximin methochloridum, and control group were treated with atropine and pyraloximin methochloridum. The effects were compared. Results Long-acting Tuoning could shorten the time of apparent manifestation of AOPP （M-like symptom disappearance time was 1.2 h in therapy group and 5.0 h in control group, with a significant difference, P（0.05）. The curing rate was increased and death rate was decreased, which were 98% and 2% in therapy group and 80.75% and 19.15% in atropine group. The number of patients with atropine poisoning reduced （3 in therapy group and 14 in control group） ; the average hospitalization duration shortened （4 - 5 d in therapy group and 7- 10 d in control group） with the decreased death rate of atropine poisoning （0 and 17% in the two groups）. Conclusion Long-acting Tuoning is an ideal cholinolytic to treat acute organophosphorus pesticide poisoning.

关 键 词：急性有机磷农药中毒 长托宁 阿托品 

分 类 号：R135.1[医药卫生—劳动卫生]