辛伐他汀对高脂血症兔主动脉内皮细胞非神经性M受体的影响  

Effect of simvastatin on non-neuronal M cholinoceptor of rabbit aorta endothelium with hyperlipemia

作　　者：李军[1] 王倩[2] 王汝欢[2] 龙超良[1] 汪海[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]北京恩华医药研究院,北京100039

出　　处：《中国临床药理学与治疗学》2006年第11期1270-1274,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探索辛伐他汀降脂治疗对介导内皮依赖性血管舒张的内皮细胞非神经性M3受体基因表达的影响。方法:高脂饮食饲喂诱发兔高脂血症模型,同时设置辛伐他汀每日5mg·kg-1降脂干预,15周后,取兔血浆测定血脂指标,取主动脉环测定内皮依赖性和非内皮依赖性血管舒张活性,并取主动脉内皮细胞以RT-PCR方法检测M3亚型的表达。结果:高脂饲喂15周造成高脂血症兔模型,同时应用辛伐他汀干预可有效地降低血脂水平,提高血管的内皮依赖性舒张活性,提高介导内皮依赖性舒张活性的内皮非神经性M3基因的表达。结论:辛伐他汀可以逆转高脂血症状态下内皮非神经性M3受体的表达,改善血管的舒张活性。AIM： To investigate the effect of simvastatin on non-neuronal M3 mRNA expression of rabbit aorta with hyperlipemia. METHODS： Hyperlipemia rabbit model was induced by high lipid diet. The simvastatin group was treated with 5 mg·kg^-1 everyday for 15 weeks. Endothelium dependent relaxation responses to acetylcholine （ACh） and non-endothelium dependent relaxation respenses to nitroprusside （SNP） of thoracic aortic tings were measured respectively. The M3 mRNA expression of aorta endothelium were tested by RT-PCR. RESULTS：Compared with the hyperlipemia group, simvastatin treatment significantly degraded the plasma lipid concentration, attenuated the inhibition of endothelium dependent relaxation induced by hyperlipemia and improved the mRNA expression of M3 in aorta endothelium. CONCLUSION： Simvastatin can reverse M3 mRNA expression of aorta endothelium reduced by hyperlipemia and improve the vasedilatory activity.

关 键 词：非神经性M受体 高脂血症 内皮 血管舒张 辛伐他汀 

分 类 号：R965.2[医药卫生—药理学] R966[医药卫生—药学]