硼硅酸盐生物玻璃的制备及其体外生物活性和降解性  

PREPARATION OF BOROSILICATE GLASS AND THEIR BIOACTIVITY AND BIODEGRADABILITY IN VITRO

作　　者：宁佳[1] 王德佳 黄文旵[1] 周萘[1] 姚爱华[1] 付海罗[1] 刘欣[1] 

机构地区：[1]同济大学材料科学与工程学院,上海200092

出　　处：《硅酸盐学报》2006年第11期1326-1330,共5页Journal of The Chinese Ceramic Society

基　　金：上海市科委重大基础研究(05DJ14006)资助项目。

摘　　要：采用熔融法制备了NaO–CaO–SiO_2–P_2O_5–B_2O_3玻璃,用质量损失分析、pH值测定和X射线衍射、电子显微镜以及电感耦合等离子体离子浓度分析法表征玻璃与稀K2HPO4溶液的类生物反应,研究了这类玻璃的生物活性和生物降解性。结果表明当玻璃中B_2O_3/SiO_2的摩尔比为31时,生物活性较好。随着B_2O_3与SiO_2的摩尔比减小,玻璃的降解速度变慢,获得的羟基磷灰石结晶度较低。利用此特性可控制生物玻璃的降解速度,从而与骨细胞生长速度相匹配。因此,此类硼硅酸盐生物活性玻璃有望在硬组织工程支架材料中得到应用。Glasses in an NaO-CaO-SiO2-P2O5-B2O3 system were prepared by a melting process. The reaction of these glasses with dilute K2HPO4 solution was characterized by mass loss analysis, pH value measurement, X-ray diffraction, scanning electron microscopy and inductance coupling plasma ion analysis. The bioactivity and biodegradability of these glasses were investigated extensively. The results show that the glass with the molar ratio of B2O3 to SiO2 of 3：1 has the best bioactivity of these glasses. The biodegradability rate and crystallinity of hydroxyapatite of the glasses decrease with the decrease of the molar ratio of B2O3 to SiO2. This implies that the biodegradability can be controlled by regulating the glass composition, and can therefore be adjusted to match the growth rate of bone cells. Therefore, this kind of bioactive borosilicate glass shows promise for application in the fabrication of scaffolding in hard tissue engineering.

关 键 词：硼硅酸盐玻璃 硼酸盐玻璃 生物玻璃 生物活性 生物降解性 

分 类 号：TB321[一般工业技术—材料科学与工程]