新Vierordt法测定复方奥美沙坦酯片中两组分溶出度  

Determination of the Dissolutions of Two Components in Compound Olmesartan Medoxomil Tablets by New Vierordt Method

作　　者：初虹[1] 马成孝 周友诚[1] 

机构地区：[1]苏州东瑞制药有限公司研发中心,江苏苏州215128

出　　处：《药学进展》2006年第12期559-562,共4页Progress in Pharmaceutical Sciences

摘　　要：目的：探讨复方奥美沙坦酯片中奥美沙坦酯和氢氯噻嗪两组分溶出度测定新方法。方法：采用新Vierordt法，不经提取分离直接测定复方奥美沙坦酯片中两组分含量和溶出度。测定波长为：Al=256．8mm，λ2=271．4nm。结果：奥美沙坦酯和氢氯噻嗪的线性范围分别为2～12mg/L（r=0．9999）和1．25～7．5mg／L（r=0．9999），其平均回收率分别为（99．75±0．93）％和（100．31±0．125）％。本法与HPLC法测定结果无显著差异（P〉0．05）。结论：本法操作简便、快速，可消除两组分的相互干扰，具较大灵活性和实用性。Objective： To investigate a new method for determination of the dissolutions of olmesartan medoxomil and hydrochlorothiazide in compound olmesartan medoxomil tablets. Methods： The new Vierordt spectrophotometry was used to determine directly the contents and dissolutions of the two components in the tablets without any preliminary separation. The detection wavelengths were 256.8 nm（λ1）and 271.4 nm（）L2）. Results： The linear ranges of Olmesartan Medoxomil and hydrochlorothiazide were 2-12 mg/L（ r = 0.9999） and 1.25-7.5 mg/L（ r = 0.9999） respectively. The mean recoveries thereof were（99.75 ± 0.93） % and （100.31 ± 0. 125） % respectively. There was no significant difference in result of determination by the method and by HPLC（P 〉 0.05））. Conclusion： The method is simple, rapid , flexible and practical. It can eliminate the mutual interference of the two components.

关 键 词：新VIERORDT法 奥美沙坦酯 氢氯噻嗪 溶出度 

分 类 号：R927.2[医药卫生—药学]