胆固醇对二棕榈酰磷脂酰胆碱（DPPC）多层膜结构的影响  

THE EFFECT OF CHOLESTEROL ON THE STRUCTURE OF DPPC MULTILAYERS

作　　者：徐育敏[1] 

机构地区：[1]清华大学生物科学与技术系生物膜与膜生物工程国家重点实验室

出　　处：《生物物理学报》1996年第2期223-226,共4页Acta Biophysica Sinica

基　　金：国家自然科学基金

摘　　要：用小角Ｘ射线衍射（ＳＡＸＤ）和差示扫描量热（ＤＳＣ）方法研究胆固醇对二棕榈酸磷脂酰胆碱多层膜结构的影响。在不同胆因醇浓度及不同温度下的衍射实验和热吸收曲线实验显示纯磷脂的尖锐的凝胶－液晶相变随胆固醇含量增加而逐渐消失。当胆固醇含量约为４０（ｍｏｌ）％或更多时，衍射曲线和热吸收曲线均显示存在分相现象。The effect of cholesterol on the stryctyre of dipalmitoylphosphatidyl-choline(DPPC)multilayers has been studied by SAXD(small angle x-ray diffraction) and DSC(differential scanning calorimetry)techniques. DSC thermograms showed that the sharp,highly cooperative phase transition in DPPC disappeared gradually with increasing of the cholesterol content.At a cholesterol concentration of 40(mol)% or more,a phase separation was observed in both x-ray diffraction and DSC experiment.

关 键 词：生物膜 胆固醇 二棕榈 酰磷脂酰胆碱 膜结构 

分 类 号：Q734[生物学—分子生物学]