Histamine H3 receptor antagonist clobenpropit enhaces GABA release to protect against NMDA -induced excitotoxicity in cultured cortical neurons through the cAMP/PKA pathway  

Histamine H3 receptor antagonist clobenpropit enhaces GABA release to protect against NMDA -induced excitotoxicity in cultured cortical neurons through the cAMP/PKA pathway

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作  者:Dai Hai-Bin Fu Qiu-Li Shen Yao Chen Zhong 

机构地区:[1]Department of Pharmacy, Second Affiliated Hospital, School of Medicine,Zhejiang University, Hangzhou, 310009 [2]Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, 310031

出  处:《中国药理通讯》2006年第4期22-22,共1页

基  金:This project was supported by grants from the National Natural Science Foundation of China (30572176 and 30600757) and the Zhejiang Provincial Natural Science Foundation of China (R303779)

关 键 词:组胺H3受体拮抗剂 CLOBENPROPIT GABA释放 NMDA诱发兴奋毒性 皮质神经元 cAMP/PKA通道 

分 类 号:R964[医药卫生—药理学] R971[医药卫生—药学]

 

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