Astograph法测定咳嗽变异型哮喘患者的气道高反应  

Provocative test of patients with cough variant asthma using Astograph

作　　者：刘庆锋[1] 邱力军[2] 解力新[1] 余秉翔[1] 马秀清[1] 郝峰英[1] 

机构地区：[1]解放军总医院呼吸科,北京100853 [2]第四军医大学生物医学工程系,西安710033

出　　处：《武警医学》2006年第12期890-893,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的比较52例咳嗽变异型哮喘患者(CVA)和35例健康人支气管激发试验和肺功能指标,并分析两指标间的相关性。方法气道反应性测定使用Astograph J-21,数据分析采用SPSS 11.0软件包,统计方法为方差分析、t检验、多重线性和逐步回归。结果126例胸部X片无明显异常的慢性咳嗽患者中,CVA确诊率为41.3%(52/126),激发试验阳性率100%(52/52),健康组激发试验阳性率0(0/35)。临床常用的指标PEF(L/s)、FEV1(L),组间差异有统计学意义(P<0.01),但反映小气道水平的MMEF、P50等指标组间差异更为显著。回归发现Dmin与P50、FEV1和BMI指数相关,PD35指标与P50、MMEF改善率、FEV1改善率及BMI指数相关。结论MMEF、P50等小气道指标要较PEF、FEV1更能体现两组间肺功能指标的差异,对CAV的诊断更具临床意义。Objective To compare the provocative and pulmonary function test results of 52 patients with cough variant asthma （CVA） and 35 healthy subjects and to assess the correlation of the two parameters between the two groups. Methods Airway responsiveness was measured with an Astograph J-21. Results were analysed by analysis of variance and stepwise regression using SPSS 11.0 software. Results Among 126 chemic cough patients with normal X- ray ,52 were found to have C＇VA （52/126,41.3%） and they all were positive to the provocative test（52/52）, whereas none in the healthy group was positive （0/35）.Thare were very significant differences in PEF（L/s） and FEVx （L） between the two groups（ P 〈 0.01） ; MMEF and P50 which reflect the damage of small airway tract were found to be even more highly sensitive parameters to reveal CVA. Besides, P50, FEVx and BMI were strongly correlatied with Drain while PD35 was correlated with P50, improvemont rate of MMEF,improvement rate of FEW1, and BMI. Conclusions MMEF and P50 are more sensitive than PEF and FEV1 as parameters to find CVA patients.

关 键 词：Astograph 咳嗽变异性哮喘 气道高反应 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]