外磁场引导下顺磁纳米铁核素的靶向治疗的理论模型(英文)  

A Theoretical Model for Targeting Therapy With the Particles of the Paramagnetic Nanometers-iron Nuclide Guided by Outside Magnetic Field

作　　者：郭萍[1] 熊平[1] 郭长青[2] 陈铀[2] 何继善[1] 

机构地区：[1]中南大学信息物理工程学院生物医学工程研究所,湖南长沙410083 [2]南华大学数理学院,湖南衡阳421001

出　　处：《中国医学物理学杂志》2006年第6期458-461,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(批准号:30371626);湖南省自然科学基金(批准号:04gjj6001);湖南省教育厅重点项目(批准号:05A045)资助

摘　　要：应用电磁场理论确定引导磁场下顺磁纳米铁核素(PNINs)的运动规律及理论模型。该数学模型及计算机模拟结果成功地解释了铁磁性药物颗粒在引导磁场的作用下随磁场的变化关系,且铁磁性药物颗粒在外引导磁场的作用下能够在靶部位定位分布。理论结果与文献中已发表的实验结果相吻合。A theoretical model for the magnetic forces on ferromagnetic drug particles in a guiding magnetic field is established with the consideration of the electromagnetic field theory, Our model shows that the ferromagnetic drug particles can concentrate on the targeted area with the guidance of the outside magnetic field. Both the distribution of the intensity of the guiding magnetic field and the forces on ferromagnetic drug particles are studied numerically, The theoretical results are in good agreement with the experimental results reported recently.

关 键 词：顺磁纳米铁核素(PNINs) 靶向治疗 引导磁场 数值模拟 

分 类 号：R318.19[医药卫生—生物医学工程]