吸入由高原现场空气平衡的一氧化氮气体治疗急性高原病的临床效果观察  

The effect of the therapy on acute high altitude disease by inhaling nitrogen monoxidum air balanced in plateau

作　　者：李素芝[1] 郑必海[1] 何祎[1] 王洪斌[1] 李红[1] 曲涛[1] 

机构地区：[1]西藏军区总医院全军高山病防治研究中心实验室,西藏拉萨850007

出　　处：《中国医师杂志》2006年第12期1631-1633,共3页Journal of Chinese Physician

摘　　要：目的通过对比观察了解高原现场空气平衡的一氧化氮（NO）对急性高原病的治疗效果。方法将47例急性高原病患者随机分为2组，一组为常规药物治疗组（23例），另一组为NO治疗组（24例）。常规药物治疗组给予吸氧、氨茶碱、地塞米松、速尿等药物治疗。NO治疗组仅给予吸入由高原现场（海拔3658米）空气平衡的0．001％的NO气体，2次／d，上午、下午各1h。并对两组治疗前及治疗后第3天的临床症状、体征及临床症状评分的变化情况进行观察比较。结果2组患者治疗后的第3天临床症状、体征及临床症状评分与治疗前比较，均有显著的改善，其中以NO治疗组效果显著（药物组P〈0.05—0．01，NO组P〈0．05—0．001），2组治疗后的症状评分比较差异有统计学意义（P〈0．05）。结论NO对急性高原病具有积极的治疗作用，其效果优于常规药物治疗。Objective To observe the effect of the therapy using NO with plateau air balance on acute high altitude disease. Methods Forty-seven acute high altitude disease patients were selected and divided into two groups randomly ： twenty-three cases as a routine drug treatment group which used the protocol of inhaling oxygen and the drugs including Aminophylline, DEX and Frusemide, while twentyfour cases as a NO treatment group which only used the protocol of inhaling 0. 001% NO gas air balanced in plateau （altitude 3,658 m）twice daily, an hour each. Observe the two groups＇clinical symptoms, physical signs and clinical symptomg scores before and after the three day treatment. Results The clinical symptoms, physical signs and clinical symptom＇s scores of the two groups after the three day treatment improved significantly. The effect of the NO treatment group was more significant （the drug group P 〈0. 05 ～0. 01d, the NO group P 〈0. 05 ～ 0. 001 ） and the scores of the clinical symptom of the two groups were also significantly different （ P 〈 0. 05 ）. Conclusion NO has a positive therapeutical effect which surpasses the routine drug treatment on acute altitude disease.

关 键 词：高原病/治疗 一氧化氮/治疗应用 

分 类 号：R594.3[医药卫生—内科学]