昆明山海棠霜抗炎止痒作用及皮肤毒性的实验研究  

Efficiency and Dermal Toxicity of Tripterygium Hypolaucum Cream

作　　者：李顺英[1] 赵永娜[1] 何黎[2] 张晓冬[1] 杨洪[2] 张肇玖[1] 唐应发[1] 

机构地区：[1]昆明医学院,昆明650031 [2]昆明医学院第一附属医院,昆明650032

出　　处：《中国中西医结合皮肤性病学杂志》2006年第4期192-194,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：云南省教育厅自然科学基金资助(03Y451C)

摘　　要：目的为了探讨昆明山海棠外用的药效及安全性,对昆明山海棠霜进行了止痒、抗炎作用及皮肤毒性的实验研究。方法二甲苯致小鼠耳廓肿胀法,磷酸组织胺致痒法,皮肤急毒、刺激及过敏等实验方法。结果昆明山海棠霜外用能明显提高豚鼠致痒阈,对二甲苯致小鼠耳廓肿胀无明显抑制作用,昆明山海棠霜外用未发现急性毒性及皮肤过敏反应。浓度较高时对家兔破损皮肤及完整皮肤有轻度刺激性,停药后皮肤刺激性反应可完全消退。结论昆明山海棠霜外用具有止痒作用且比较安全。Objective To approach the efficiency and safety of Tfipterygium hypoglaucum（Lever） Hutch（THH） cream that used extemally. The experimental research on anti-inflammatory, antipmfitic effect and dermal toxicity of THH cream. Methods Pruritus induced by histamine, mice＇s extemal ears swelling induced by dimethly benzene, dermal acute toxicity, cutaneous irritation and sensitization. Reactions were used in the experiment. Results THH cream can significantly elevate the pruritus threshold of guinea pigs. It has no significant inhibited effect on mice＇s extemal ears swelling induced by dimeth- ly＇benzene. We find no acute toxicity reaction and hypersensitiveness reaction on skin of THH cream that used extemally. High concentration THH cream has slight stimulation to both damaged and intact skin of rabbits. The stimulation on skin can disappear completely after withdrawal. Conclusion THH has antipruritic effect and is safe when used extemally.

关 键 词：昆明山海棠霜 抗炎 止痒 皮肤毒性 

分 类 号：R285.5[医药卫生—中药学]