甲真菌病患者T细胞亚群检测及意义探讨  

Analysis of T-cell Subsets in Patients with Onychomycosis and its Significancechronic

作　　者：戴溱[1] 赵桂华[1] 赵百合[1] 李振化[1] 张宇[1] 聂振华[1] 

机构地区：[1]天津长征医院,天津300120

出　　处：《中国中西医结合皮肤性病学杂志》2006年第4期207-208,共2页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的观察甲真菌病人群T细胞亚群的变化,进而探讨甲真菌感染与人体免疫的关系。方法应用免疫荧光法对60例甲真菌病患者的外周血T细胞亚群进行检测。结果甲真菌病患者的外周血CD3+、CD4+、及CD4+/CD8+比值明显降低(P<0.05),CD8+明显升高(P<0.05)。结论甲真菌病患者T细胞亚群存在异常。提示细胞免疫在甲真菌病的发病中起着一定的作用。Objective To investigate the changes of paripheral T lymphocytes in patients with onychomycosis and the relationship between fungus infection of nails and immune function. Methods Peripheral T cell subsets in 60 patients with onychomycosis were detected by immunofluorescence. Results The results showed that the proportion of CD3^＋, CD4^＋, T lymphocytes and the CD4^＋/CD8^＋ retio are significantly lower （P〈0.05） and the proportion of CD8^＋T lymphocytes are significantly higher （P〈0.05） than normal controls. Conclusion The subsets of T lymphocytes should be changed in onychomycosis, which may play a role in pathogenesis of onythomycosis.

关 键 词：甲真菌病 T细胞亚群 细胞免疫 

分 类 号：R756.4[医药卫生—皮肤病学与性病学]