抗环瓜氨酸肽抗体和类风湿因子联合测定对类风湿关节炎的诊断价值  

The Diagnostic Value of Combinate Determination of Anti-cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for the Rheumatoid Arthritis

作　　者：曾瑜[1] 陈明[2] 蔡美珠[1] 刘琦[2] 顾耀林[2] 王开正[1] 

机构地区：[1]泸州医学院附属医院检验科,四川泸州646000 [2]泸州医学院附属医院肾内科,四川泸州646000

出　　处：《中国临床医学》2006年第6期1022-1023,共2页Chinese Journal of Clinical Medicine

摘　　要：目的：探讨联合检测抗环瓜氨酸肽抗体(抗CCP抗体)及类风湿因子(RF)对类风湿性关节炎(RA)的临床诊断价值。方法：分别用ELISA法、速率散射比浊法联合检测66例RA患者和48例非RA的风湿病患者的血抗CCP抗体和RF。结果：抗CCP抗体和RF联合检测的特异性、阳性预测值、阳性似然比、阴性似然比与任何单一项检测比较均有显著差异(P＜0．05)。结论：联合检测抗CCP抗体和RF可明显提高类风湿性关节炎的诊断率。Objective：To evaluate the clinical diagnosie value of anti-cyclic eitrullinated peptide（anti-CCP） antibody and rheu matoid factor（RF） in patients with rheumatoid arthritis（RA）. Methods：Anti-CCP antibody was defected by quantitative ELISA and rheumatoid factor by BNP nephelometer in 66 cases of RA and 48 cases of non-RA rheumatic diseases. Results; The diag nosis specificity, positive predictive value, positive/negative likelihood ratios of combinate determination of anti-CCP antibody and RF were significantly higher than either one. Conclusion： The measurements of anti-CCP antibody and rheumatoid factor will remarkably improve the accuracy of diagnosis of RA.

关 键 词：抗CCP抗体 类风湿因子 类风湿性关节炎 

分 类 号：R446.62[医药卫生—诊断学]