复方普鲁卡因对小鼠、蟾蜍神经干阻断作用的实验研究  

THE EXPREIMENTAL STUDY OF PROCAINE COMPOUND BLOCKING ACTION IN MOUSE AND TOAD NERVE TRUNK

作　　者：李清漪 邱丽萍 许莉 焦文才 宋本海[2] 孙旭光[2] 梁桂林[2] 张业 李雪岩 孟庆芳 

机构地区：[1]药理学研究室 [2]教学医院.齐齐哈尔市第一医院 [3]生理学教研室

出　　处：《齐齐哈尔医学院学报》1996年第3期169-171,共3页Journal of Qiqihar Medical University

摘　　要：复方普鲁卡因对小鼠坐骨神经干麻醉作用：ＥＤ５０量是１．３４ｍｇ，麻醉效力是普鲁卡因的１．９６１倍，是利多卡因的０．７５４倍，０．９５％复方普鲁卡因麻醉持续时间长于同浓度普鲁卡因，Ｐ〈０．０５，短于同浓度的利多卡因，Ｐ〈０．０１。１．９％复方普鲁卡因１０μｌ（２９．８３×１０＾４μｍｏｌ／Ｌ）对蟾蜍坐骨神经标本麻醉作用：５分钟内动作电位衰减率近１７±３．６％（Ｘ↑－±ＳＤ），而同浓度。The anesthesia action of Procaine Compound ( Pco. ) in mouse sciatie nerve: ED50was 1.34mg; The anesthesia efficiency wasl.961 times of Procaine ( P ) and 0.754 times of Lidocaine ( L ) ; The anesthesia maintenance time of 0.95% Pro.was longer than that of the same concentration P(P<0.05)and shorter than that of the same concentration L ( P<0.01 ) .The anesthesia action of 1.9% Pco.10ul ( 29.83×104 umol/L) in tode sciatic nerve preparation. The attenution rate of Action Potential ( Apc ) approximated 17±3.6% (X±SD) in 5 minutes.That of the same dose and concentration of P.andL. were 19.2±5.1%, 21.1±3.0% respectively in 7 minutes.The results show that the anesthesia action of 1.9% Pco.in tode sciatic nerve trunk is powerful than that of P and L.

关 键 词：普鲁卡因 利多卡因 神经干阻断作用 

分 类 号：R971.2[医药卫生—药品]