盐酸戊乙奎醚对高黏血症大鼠微循环和血液流变性的影响  

Effect of Penehyclidine Hydrochloride on Hemorrheology and Microcirculation in Hyperviscosity Rats

作　　者：刘耀武[1] 马腾飞[1] 蒋新颖[2] 谷淑玲[1] 

机构地区：[1]徐州医学院药理教研室,江苏徐州221002 [2]徐州医学院附属医院检验科

出　　处：《中国微循环》2006年第6期415-418,共4页Journal of Chinese Microcirculation

摘　　要：目的观察盐酸戊乙奎醚(Penehyc lid ine Hydrochloride,PHC)对大鼠肠系膜微循环及血液流变性的影响。方法健康成年SD大鼠舌静脉给予10%的高分子右旋糖酐(h igh molecu lar dextran,HMD)3.5 m l/kg制造高血黏症动物模型,镜下活体观察大鼠肠系膜微循环微血流流态变化,造模成功后给予PHC 0.023、0.07、0.2 mg/kg,山莨菪碱(an isodam ine,An i)2 mg/kg,生理盐水2 m l/kg,继续观察微血流流态变化。给药后40 m in取血做血液流变性检测及血栓烷素A2(thromboxan A2,TXA2)与前列环素(prostagland in I2,PG I2)含量测定。结果模型组与正常对照组比较,血流明显变缓,血流态为粒摆流或近停滞状态,全血黏度、血浆黏度、红细胞比容、红细胞电泳时间、血沉方程K值、TXA2及TXA2/PG I2均有极显著性差异(P<0.01);PHC 0.2 mg/kg组能明显改善血浆黏度,在PHC 0.023、0.07、0.2mg/kg及An i 2 mg/kg组除血浆黏度外均得到明显改善,与模型组比较P<0.05。结论PHC可改善HMD引起的急性微循环障碍及血液流变性异常。Objective To observe the effect of penehyclidine hydrochloride（PHC） on improving abnormal hemorrheology and microcirculatary disturbance on rat＇ s mesentery. Methods Normal adult SD rats were induced of syndrome of high blood viscosity by lingual vein injecting 10% high molecular dextran（HMD） 3.5ml/kg, then variation of bloodstream on mesentery was observed under the stereomleroscope. They were divided into 5 groups, injecting PHC 0. 023mg/kg, 0.07mg/kg, 0.2mg/kg, anisodamine（Ani） 2mg/kg, NS. 2mi/kg respectively, and continuing to observe variation of bloodstream. 40min later, drew blood for hemorrheology detection, contents of thromboxan A2（ TXA2） and prostaglandin I2 （PGI2） were also measured. Results There is significant difference in bloodstream, blood viscosity, plasma viscosity, volume of packed red blood cell, erythrecyte electrophoretic time, K value of blood sedimentation equation and contents of TXA2and TXA2/ PGI2 in model group, compared with those in normal group. PHC 0. 2mg/kg group can obviously deexease plasma viscosity. Other indexes have greatly improved in groups of PHC 0. 023mg/kg, 0. 07mg/kg, 0. 2mg/kg, Ani 2mg/kg, compared with those in model group. Conclusion Penehydidine Hydrochloride can improve acute dysfunction of microcireulation and abnormal hemorrheology induced by high molecular dextran.

关 键 词：盐酸戊乙奎醚 微循环 血液流变性 TXA2/PGI2 

分 类 号：R961[医药卫生—药理学] R331.35[医药卫生—药学]