西安地区健康人群血清总胆红素和直接胆红素参考值调查  

The Investigation of Serum Total Bilirubin and Direct Bilirubin Within Healthy Crowd in Xi'an Area

作　　者：阴斌霞[1] 王香玲[1] 赵丽华[1] 耿燕[1] 王小利[1] 朱建宏[1] 黄芳[1] 李淑琴[1] 何谦[1] 

机构地区：[1]西安交通大学第二附属医院,陕西西安710004

出　　处：《实用医技杂志》2006年第23期4234-4236,共3页Journal of Practical Medical Techniques

基　　金：陕西省科技攻关项目[2002K10-G6(5)]

摘　　要：目的:探讨西安地区健康体检人群血清胆红素水平。方法:采用回顾分析的方法,随机抽取1007例在我院例行健康查体人群的血清总胆红素(TBIL)和直接胆红素(DBIL)的测定值,按不同年龄、性别、职业进行分组统计分析,并与北京、四川崇州、山东威海、广东茂名地区人群进行比较,观察胆红素参考值的变化。结果:西安地区健康体检人群血清TBIL、DBIL水平比原参考值明显上升(P<0.01),成年男性血清TBIL水平(14.38±6.39)μmol/L,75百分位数(P75)和95百分位数(P95)分别为16.40和25.89,DBIL(4.08±2.46)μmol/L,P75和P95分别为6.00和8.90。成年男性血清TBIL(14.08±6.58)μmol/L,DBIL(5.10±2.57)μmol/L,成年女性血清TBIL(12.42±6.00)μmol/L,DBIL(4.74±2.27)μmol/L,男性大于女性,不同性别、年龄、职业人群TBIL差异极有显著性(P<0.01)。TBIL现参考值超限检出率(5.3%)明显低于原参考值(10.5%),DBIL现参考值(8.7%)低于原参考值(15.7%),超限检出率降低44%以上。西安地区健康体检人群TBIL、DBIL水平与北京、四川崇州、山东威海、广东茂名地区人群有差异(P<0.05或P<0.01)。结论:西安地区健康体检人群TBIL、DBIL水平与原参考值发生了改变,原参考值已不能较好的适用临床和健康体检的需要,应科学、合理的建立地区性的胆红素参考值。Objective To investigate the serum Bilirubin level within healthy crowd in Xi＇an area. Methods The high-level automatic biochemical analyzer（ 日立 7600-020） was used to detect the level of TBIL/DBIL of 1007 cases obtained randomly from the normal physical examination in our hospital and divided it into different groups by age, gender, profession,and area, analyzed by the retrospective investigation. Results The whole level of TBIL/DBIL in xi＇an area are higher than the original reference level （P 〈 0.01 ）. The average level of TBIL is 14.38μmol/L ± 6.39 μmol/L, and it＇s P75 and P95 are 16.40 and 25.89 respectively, DBIL 4.08μmol/L ± 2.46 μmol/L, and it＇s P75 and P95 are 6.00, and 8.90 respectively. The level of TBIL/DBIL （ 14.08 ± 6.58, 5.10 ± 3.57） in adult males are higher than the ones from adult female （ 12.42 ± 6.00, 4.74 ± 2.27）, and there is a significent difference between different ages, genders, and profession（ P 〈 0.01 ）. There is a difference between the level of TBIL/DBIL of Xi＇an area and other area such as Beijing, Chongzhou in Sichuan , Weihai in Shandong, Maoming in Guangdong（P 〈 0.05 or P 〈 0.01 ）. Conclusion The study demonstrated there is a change between the present serumal levels of TBIL and DBIL and the original reference values, which is not able to properly meet the clinical needs. It＇s necessary to establish a new reference values system scientifically and reasonably.

关 键 词：西安地区 健康人群 总胆红素 直接胆红素 参考值 

分 类 号：R195[医药卫生—卫生统计学]