湖北贝母茎叶非生物碱成分的研究  

Studies on Non-alkaloid Constituents from the Stem and Leaf of Fritillaria Hupehensis

作　　者：张久亮[1] 皮慧芳[1] 阮汉利[1] 张勇慧[1] 吴继洲[1] 

机构地区：[1]华中科技大学同济医学院药学院,武汉430030

出　　处：《医药导报》2007年第1期23-25,共3页Herald of Medicine

摘　　要：目的研究湖北贝母茎叶部分非生物碱部位的化学成分。方法对湖北贝母茎叶部分的乙醇提取物进行萃取分离,分成生物碱部位和非生物碱部位,应用溶剂极性梯度从非生物碱部位获得了几个化学部位,并应用硅胶柱层析对醋酸乙酯部位进行分离纯化,从中分离出5个单体化合物,应用质谱、氢谱、碳谱等现代波谱技术加以鉴定。结果鉴定得到5个化合物,分别为CH3(CH2)26CH3、CH3(CH2)24OH、CH3(CH2)20COOH、β-谷甾醇(β-sitosterol)和胡萝卜苷(daucosterol)。结论5个化合物均为首次从湖北贝母茎叶部分分离所得,其中前3个化合物为首次从贝母属植物中获得。Objective To study the chemical constituents from the stem and leaf of Fritillaria hupehensis. Methods The stem and leaf of Fritillaria hupehensis were divided into two parts： alkaloids parts and non-alkaloids parts. Several chemical fractions were prepared from the non-alkaloids parts, and five compounds were purified from the acetic ether parts by the methods of the silica gel column. The five compounds were identified hy the modem spectral technology such as MS, ^1H-NMR, ^13C-NMR. Results Five compounds were isolated from the non-alkaloid parts of the stem and leaf of Fritillaria hupehensis. There were CH3 （ CH2 ）26 CH3, CH3 （ CH2 ）24 OH, CH3 （ CH2 ）20 COOH, β-sitosterol and daucostcrol. Conclusion These compounds were all obtained from the stem and leaf of Fritillaria hupehensis for the first time. And the first three compounds were got for the first time from Fritillaria.

关 键 词：湖北贝母 茎叶 非生物碱 

分 类 号：R284[医药卫生—中药学]