消旋卡多曲干混悬液的制备与稳定性考察  

Preparation of Racecadotril Suspension and Preliminary Study on Its Stability

作　　者：宋恬[1] 何再安[2] 刘焱文[2] 

机构地区：[1]湖北中医学院2005级药学硕士研究生班 [2]湖北中医学院药学院,武汉430065

出　　处：《医药导报》2007年第1期57-59,共3页Herald of Medicine

摘　　要：目的制备消旋卡多曲干混悬液。方法考察常用的羟丙基甲基纤维素(HPMC)、羧甲基纤维素钠、聚维酮、黄原胶、甲基纤维素等辅料对干混悬液的影响。通过对其沉降体积比、再分散性指标的考察,筛选了2%HPMC助悬剂,并从流变学、混悬液黏度及显微形态等方面对其稳定性进行了研究。同时考察药物加速实验下粒子形态的稳定性。结果所制干混悬液工艺简单、稳定性良好,形成的混悬液符合干混悬液的各项质量指标。结论该法所制备的消旋卡多曲干混悬液可达到干混悬液要求,制剂质量稳定。Objective To prepare racecadotril suspension. Methods The suspending effects of the following hydrophilic polymers were investigated： HPMC, CMC-Na, PVP K90, Xanthan gum and MC. Two percent of HPMC appeared to be a satisfying suspending agent by evaluating the sedimentation rate and the redispersion of racecadotril. The stability of suspension was studied by detecting the rheology property, suspension viscosity, and microscopic morphology and the stability of particle morphology under accelerated experiment of drugs was also detected. Results The obtained racecadotril suspension comformed with the quality standard. Conclusion The suspension meets the requirements of suspension preparation with stable quality.

关 键 词：消旋卡多曲 沉降体积比 助悬剂 稳定性 

分 类 号：R944.16[医药卫生—药剂学] TQ460.6[医药卫生—药学]