钩虫感染连续化疗效果分析  

Effect of consecutive chemotherapy on hookworm infections in human

作　　者：杨维平[1] 杨亮吉[2] 沈一平[3] 邵靖鸥 章涛[5] 董恺[6] 

机构地区：[1]扬州大学医学院病原生物学与免疫学教研室,225001 [2]复旦大学数学科学学院,200433 [3]南京医科大学,210029 [4]扬州市疾病预防控制中心,225001 [5]福建医科大学,福州350004 [6]江都市疾病预防控制中心,225200

出　　处：《国际医学寄生虫病杂志》2006年第6期292-295,共4页International JOurnal of Medical Parasitic Diseases

基　　金：江苏省社会发展科技项目(No.BS2004534)~~

摘　　要：目的分析试点村人群钩虫感染连续化疗的效果。方法1987-1997年间，经定量透明法和饱和盐水浮聚法对试点村人群进行钩虫感染普查，对钩虫卵阳性者主要用阿苯达唑300mg和复方甲苯达唑375mg，1．5日疗法，连续选择性化疗11年。运用统计软件R2．2．1建立负二项分布模型拟合数据，统计分析疗效。结果钩虫感染率和感染度（EPG）从化疗前的58．79％和526．29降至化疗后的1．08％和56．91，均呈“L”型下降趋势，感染率和感染度在第1—3次化疗后即降到低水平，此后维持在低水平波动。结论连续选择性化疗可使钩虫病流行区的感染率和感染度迅速下降，并维持在较低水平。Objective To analyze the effect of the consecutive chemotherapy on hookworm infected patients in intervention village. Methods With the methods of improved Kato＇s thick smear and saturated brine floatation, the general detection of hookworm eggs was performed in intervention village from 1987 to 1997, the egg positive cases were treated with albendasole 300 mg and co-mebendazole 375 mg in combination in 1.5 days. The sample group of patients in intervention village was consecutively administered a selective chemotherapy for 11 years. The data were analyzed using the negative binomial distribution through the statistic software R 2.2.1. Results The infection rate decreased from 58.79% before the chemotherapy to 1.08% after the chemotherapy, and the mean eggs per gram （EPG） changed from 526.29 to 56.91. Both of them decreased as a ＂L＂ shape. The infection rate and the mean EPG fluctuated at low level after the first to third round of chemotherapy. Conclusion The consecutive chemotherapy can decrease the infection rate and the mean EPG of the hookworm infection rapidly and keep them at lower level.

关 键 词：钩虫感染 苯并咪唑 流行病学 化疗 

分 类 号：R532.12[医药卫生—内科学]