弓形虫排泄/分泌抗原的免疫保护性研究进展  

Research progress on immunological protection of Toxoplasma gondii excreted/secreted antigens

作　　者：吴静[1] 殷国荣[1] 

机构地区：[1]山西医科大学医学寄生虫学研究所

出　　处：《国际医学寄生虫病杂志》2006年第6期309-312,共4页International JOurnal of Medical Parasitic Diseases

基　　金：山西省自然科学基金(No.20041105);山西省高校科技研究开发项目(No.20041238);山西医科大学基础医学院"学科研究方向建设基金"(No.20040708)

摘　　要：弓形虫排泄/分泌抗原(ESA)是虫体在黏附、侵入宿主细胞及在纳虫泡中寄生过程中分泌、排泄的抗原物质。近期的研究主要通过体外培养法获取ESA,并对其进行分子生物学及免疫学特性研究。ESA中的多种成分具有较强的免疫原性,可诱导细胞及体液免疫应答并产生抗弓形虫感染的保护作用。研究ESA的免疫保护作用对揭示弓形虫带虫免疫及免疫逃避机制有重要意义,对弓形虫病的诊断及免疫预防、疫苗候选抗原的制备具有重要价值。Toxoplasma gondii excreted/secreted antigens（ESA） are released during the host-cell adhesion and invasion and during the parasitism in parasitophorons vacuole. In recent researches, the ESA were prepared mainly by culture of Toxoplasma gondii in vitro, and the molecular biological and immunological characteristics of ESA were studied. Many components of ESA have potent immunogenieity, and induce protective ceil-mediated and humoral immune responses. Study of the immunological protection of ESA is necessary for revealing the mechanism of premunition and immune evasion, and valuable for the diagnosis and immunoprophylaxis of toxoplasmosis and preparation of candidate vaccine antigens.

关 键 词：弓形虫 排泄分泌抗原 保护性免疫 

分 类 号：R531.8[医药卫生—内科学]