丙泊酚和依托咪酯静脉麻醉对妇科腹腔镜手术炎症因子的影响  

Influence ropofol and etomidate intravenous anesthesia on inflammatory factor in gynaecological laparoscopic suregery

作　　者：谢才姣[1] 杨昭云[1] 徐军美 

机构地区：[1]中南大学湘雅二医院麻醉科,湖南长沙410011

出　　处：《中国内镜杂志》2006年第12期1271-1272,1281,共3页China Journal of Endoscopy

摘　　要：目的观察依托咪酯和丙泊酚静脉麻醉对腹腔镜手术炎症因子的影响。方法选择30例妇科行腹腔镜手术病人,随机分为:丙泊酚组(P组)和依托咪酯组(E组),丙泊酚组(P组)给予2mg/kg诱导,然后以4mg/(kg.h)维持;依托咪酯组(E组)给予0.3mg/kg诱导,然后以0.7mg/(kg.h)维持,诱导加用力月西1mg/kg、芬太尼5μg/kg和阿曲库铵0.6mg/kg,泵入芬太尼2μg/kg维持。观察记录并比较诱导前(T0)、插管时(T1)、气腹后5min(T2)以及手术结束(T3)时的心率、收缩压和舒张压。并于T0、T1、T2和T3抽取肘静脉血测定白介素-6和肿瘤坏死因子-α。结果在气腹后5min和手术结束时,两组IL-6都明显高于术前,E组明显高于P组;两组TNF-α之间差异无显著性。结论丙泊酚麻醉诱导和维持抑制炎症因子的作用明显强于依托咪酯。[Objective] To investigate the influence of inflammatory factor of propofol and etomidate intravenous anesthesia in gynaecological laparoseople suregery. [Methods] Thirty ASA ii patients undergoing gynaeeological laparoscopic suregery patients were randomly divided into two groups： propofol group （group P） and etomidate group （group E）, induction of anesthesia with propofol 2 mg/kg in group P and with etomidate 0.3 mg/kg, at the same time intravenous inject midazolam 1 mg/kg fentanyl 5 μg/kg and atracurium 0.6 mg/kg. Maintain with prpofol 4 mg/（kg·h） in group P and etomidate 0.7 mg/（kg·h） in group E. all patient maintaince with fentanyl 2 μg/kg. [Result] The level of IL-6 were marked higher in group E at 5 min after pneumoperitomeum and the end of operation than group P. The level of TNF-μ in two groups were no significant. [Conclusion] propofol can inhibit the levels of IL-6, lessen the inflammatory reaction resulted in operation.

关 键 词：依托咪酯 丙泊酚 白介素-6 肿瘤坏死因子-Α 麻醉 

分 类 号：R331.3[医药卫生—人体生理学]