落新妇甙对小鼠心脏移植排斥反应的抑制作用  

Suppression of cardiac allograft rejection in mice by Astilbin

作　　者：陈涛[1] 潘铁成[1] 高思海[1] 李军[1] 郑智[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,湖北武汉430030

出　　处：《山东医药》2006年第33期7-8,共2页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30300323)

摘　　要：目的探讨落新妇甙对小鼠心脏移植排斥反应的抑制作用。方法采用小鼠颈部心脏移植模型。随机将心脏移植后的48只小鼠分为四组:A组心脏移植后每天用生理盐水1 m l灌胃,B组心脏移植后每天用环孢素A 5 m g/kg灌胃,C组心脏移植后每天用落新妇甙1 m l/kg灌胃,D组心脏移植后每天用环孢素A 2.5 m g/kg及落新妇甙1 m l/kg灌胃。观察移植心脏的存活时间及心脏跳动情况。结果B组、C组及D组移植心脏存活时间均较A组显著延长(P<0.01);D组移植心脏存活时间最长,优于C组(P<0.05)和B组(P<0.01)。结论落新妇甙对心脏移植排斥反应有较强的抑制作用,并与环孢素A有协同作用。[Objective] To study the suppression effect of Astilbin on cardiac allograft rejection in mice. [Methods] The model of mice cervical heterotopic heart transplantation was set up. forty-eight heart transplanted mice were divided in to 4 groups randomly： group A were fed with normal saline （1 ml per day）, group B were fed with CsA 5 mg/kg per day,group C were fed with Astilbin 1 mg/kg per day,and group D were fed with Astilbin 1 ml/kg per day aud CsA 2.5 mg/kg per day. Grafts survival days and transplanted heart beating conditions were observed every day after heart transplantation. [Results] In group B, C and D, the survival time of the grafts was prolonged significantly as compared with group A. The survival time of the grafts in group D was prolonged significantly as compared with group C （P 〈0.05） and group B （P〈0.01）. [Conclusions] Astilbin can suppress cardiac allograft rejection,and has synergistic reaction with CsA.

关 键 词：心脏移植 落新妇甙 排斥反应 

分 类 号：R654.1[医药卫生—外科学]