不同体重指数不同糖耐量状态下人的血清抵抗素水平  

Serum resistin level in subjects with different body mass indexes and glucose tolerance statuses

作　　者：于学满[1] 赵晓娟[1] 孙小东 

机构地区：[1]中国医科大学附属第一医院内分泌科,辽宁沈阳110001 [2]鞍山市铁西区中医院内科

出　　处：《中国医科大学学报》2006年第1期54-55,共2页Journal of China Medical University

摘　　要：目的:探讨不同体重指数(BM I)、不同糖耐量(GT)状态下人血清抵抗素水平与胰岛素抵抗(IR)的关系。方法:2型糖尿病(T2DM)患者、正常糖耐量者(NGT)及糖调节受损者(IGR)分别按BM I≥25 kg/m2分为肥胖与非肥胖,采用酶联免疫分析法检测空腹血清抵抗素水平,并以稳态模型(HOMA-model)计算胰岛素抵抗指数(HOMA-IR)。结果:T2DM组和NGT组中的肥胖者血清抵抗素水平均高于非肥胖者,T2DM组有统计学意义(P<0.05);IGR组血清抵抗素水平高于T2DM组及NGT组。空腹血清抵抗素与BM I、HOMA-IR呈正相关,与甘油三酯、空腹胰岛素及餐后2 h胰岛素呈正相关;与空腹血糖、腰臀比无明显相关性。结论:抵抗素可能在肥胖发展为糖尿病的过程中,成为预测糖尿病发病的一个指标。Objective： To study the relationship between serum resistin level and insulin resistance in subjects with different body mass indexes （BMI） and glucose tolerance statuses. Methods： 52 patients with type 2 diabetes mellitus （T2DM）, 18 patients with impaired glucose regulation （IGR）, and 30 normal controls with normal glucose tolerance （NGT） were selected, and each group were divided into obese and non-obese subgroups according to BMI. The level of fasting serum resistin was measured by enzyme linked immunoadsorbent assay, and homeostasis model assessment of insulin resistance （HOMA-IR） was calculated. Results： In T2DM group and NGT group, the levels of serum resistin in obese subgroup were higher than those in non-obese subgroup. But only in T2DM group, the difference in serum resistin levels was significant （ P 〈 0.05 ）. The levels of serum resistin in IGR group was higher those in T2DM group and NGR group. The level of fasting serum resistin was positively correlated with BMI, HOMA-IR, triglyceride level, fasting insulin levd, and 2-hour postprandial insulin level. No correlation was found beth between the level of fasting serum reaistin and writst-to-hip ratio and between the level of fasting serum resistin and the level of fasting blood glucose. Conclusion： The obese subjects with T2DM and NGT have obvious insulin resistance, which is correlated closely with the level of serum resistin. Resistin may be used as an indicator to predict the occurrence of diabetes mellitus.

关 键 词：糖尿病 肥胖 抵抗素 血糖 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]