VEGF及CD34在外阴皮肤黏膜上皮内非瘤样病变及外阴上皮内瘤变中的表达  

Expression of vascular endothelial growth factor and human hematopoietic progenitor cell antigen in non-neoplastic epithelial disorders of the vulva and vulvar intraepithelial neoplasia

作　　者：杨静[1] 武昕[1] 李威[1] 赵毅[1] 

机构地区：[1]中国医科大学附属第一医院妇科,辽宁沈阳110001

出　　处：《中国医科大学学报》2006年第2期179-180,共2页Journal of China Medical University

基　　金：辽宁省科技计划基金资助项目(2001225002-15)

摘　　要：目的:探讨外阴真皮组织内血管形成及密度(MVD)改变与外阴皮肤黏膜上皮内非瘤样病变(NNEDV)及外阴上皮内瘤变(VIN)的关系。方法:血管内皮生长因子(VEGF),人原始造血细胞抗原(CD34)染色采用免疫组织化学S-P法。结果:外阴硬化性苔藓(LS)和VIN中VEGF高表达与正常皮肤比较均有显著差异(P<0.05)。LS和VIN中MVD与正常皮肤比较均有显著差异(P<0.05)。结论:LS组织中存在微循环障碍,局部缺血缺氧,代偿性刺激血管生成因子表达增高。Objective： To investigate the relationship of angiogenesis and mierovessel density （MVD） with non-neoplastic epithelial disorders of the vulva （NNEDV） and valvar intraepithelial neoplasia （VIN）. Methods： Vascular endothelial growth factor （VEGF） and human hematopoietie progeuitor cell antigen （CD34） were stained with S-P immunohistochemieal method. Results： The expression of VEGF in lichen selerosus （LS） and VIN was significantly higher than that in normal tissues （ P 〈 0.05）. The expression of CD34 in VIN was significantly higher than that in normal tissues （ P 〈 0.05）, and in LS it was significantly lower than that in normal tissues （ P 〈 0.05）. Conclusion： Microcirculation disorder may be involved in IS, and it can cause ischemia and hypoxia and stimulate high expressions of angiogenie factors.

关 键 词：外阴皮肤黏膜上皮内非瘤样病变 外阴上皮内瘤变 血管内皮生长因子 人原始造血细胞抗原 

分 类 号：R713.2[医药卫生—妇产科学]